Overview
Flavone with anti-inflammatory effects.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Inhibits mast cell activation; PDE inhibitor.
- · Inhibits mast cell activation
- · PDE inhibitor
Effects on the body
Organ system effects
Luteolin acts on central nervous system targets implicated in attention, memory, and neuroprotection.
Luteolin modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Reduces neuroinflammation (preclinical)
Moderate evidencePotential side effects
- · Well tolerated
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
- Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
- Vitamin D3 + K2Foundational immune modulation.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Luteolin — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Luteolin third party tested NSF
CapsulesPre-measured Luteolin capsules — easiest for travel and consistent daily dosing without scoops or scales.Luteolin capsules
PowderBulk unflavored Luteolin powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Luteolin powder unflavored
Best sellersMost-purchased Luteolin products on Amazon — a quick way to see what's reviewed widely before you commit.Luteolin best sellerScientific evidence8Show studiesHide studies
Luteolin in autism
Theoharides TC, et al.
37 ASD children
Improved adaptive functioning.
PubMed: Luteolin — Reduces neuroinflammation
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PubMed: Luteolin — randomized controlled trial
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PubMed: Luteolin — meta-analysis
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PubMed: Luteolin — safety adverse events
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PubMed: Luteolin — dose response
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Google Scholar: Luteolin — clinical evidence
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Cross-database citation index for Luteolin as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.