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evidence · mechanism · dose
Supplements/Mineral

Selenium-Enriched Yeast

Yeast-bound selenomethionine — form used in major chemoprevention trials.

Thyroid SupportImmune FunctionHealthy Aging

Overview

Yeast-bound selenomethionine — form used in major chemoprevention trials.

Natural sources
    Common forms

      Forms & variants of Selenium

      Different chemical forms of Selenium behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Selenium

      Trace mineral essential for glutathione peroxidase and thyroid hormone activation.

      Selenomethionine
      Selenomethionine

      Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.

      Mechanism of action

      Selenomethionine incorporated into proteins and slowly released as needed.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces anti-TPO antibodies in Hashimoto's

        Strong evidence

        Potential side effects

        Common
          Rare
          • · Garlic breath
          Serious
          • · Selenosis >400 mcg long-term

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid with these conditions
          • ·Autoimmune disease (theoretical immune activation)
          Avoid / monitor with these medications
          • ·Immunosuppressants

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          100–200 mcg
          With food?
          With meals

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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          iHerb
          Global delivery · curated brands
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          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTJ Clin Endocrinol Metab · 2002

          Selenium in Hashimoto's

          Gärtner R, et al.

          3-month DB-RCT in 70 patients.

          Key findings

          200 mcg/day reduced TPO antibodies by 40% vs placebo.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Selenium-Enriched Yeast — Reduces anti-TPO antibodies in Hashimoto's

          Live PubMed search

          Live results for "Selenium-Enriched Yeast Reduces anti-TPO antibodies in Hashimoto's" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Selenium-Enriched Yeast and "Reduces anti-TPO antibodies in Hashimoto's". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Selenium-Enriched Yeast — randomized controlled trial

          Live PubMed search

          Live results for "Selenium-Enriched Yeast randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Selenium-Enriched Yeast and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Selenium-Enriched Yeast — meta-analysis

          Live PubMed search

          Live results for "Selenium-Enriched Yeast meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Selenium-Enriched Yeast and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Selenium-Enriched Yeast — pharmacokinetics

          Live PubMed search

          Live results for "Selenium-Enriched Yeast pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

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          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Selenium-Enriched Yeast — safety adverse events

          Live PubMed search

          Live results for "Selenium-Enriched Yeast safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Selenium-Enriched Yeast and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Selenium-Enriched Yeast — dose response

          Live PubMed search

          Live results for "Selenium-Enriched Yeast dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Selenium-Enriched Yeast and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Selenium-Enriched Yeast — clinical evidence

          Live Scholar search

          Cross-database citation index for Selenium-Enriched Yeast as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.