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Supplements/Mushroom

Phellinus Linteus

Meshima mushroom with hispolon for immune support.

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Overview

Meshima mushroom with hispolon for immune support.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Hispolon modulates NF-κB and apoptosis pathways.

Pathways
  • · Hispolon modulates NF-κB
  • · apoptosis pathways

Effects on the body

Supports
Immune modulator

Organ system effects

Immune System

Phellinus Linteus modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Immune modulator

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Phellinus Linteus use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with
      • Vitamin D3 + K2
        Foundational immune modulation.
      • Zinc
        Required cofactor for innate and adaptive immune function.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500–1500 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      AnimalCancer Sci · 2008

      Phellinus linteus polysaccharide

      Zhu T, et al.

      Animal tumor models

      Key findings

      Inhibited tumor growth and metastasis.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phellinus Linteus — Immune modulator

      Live PubMed search

      Live results for "Phellinus Linteus Immune modulator" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phellinus Linteus and "Immune modulator". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phellinus Linteus — randomized controlled trial

      Live PubMed search

      Live results for "Phellinus Linteus randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phellinus Linteus and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phellinus Linteus — meta-analysis

      Live PubMed search

      Live results for "Phellinus Linteus meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phellinus Linteus and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phellinus Linteus — pharmacokinetics

      Live PubMed search

      Live results for "Phellinus Linteus pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phellinus Linteus and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phellinus Linteus — safety adverse events

      Live PubMed search

      Live results for "Phellinus Linteus safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phellinus Linteus and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phellinus Linteus — dose response

      Live PubMed search

      Live results for "Phellinus Linteus dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phellinus Linteus and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Phellinus Linteus — clinical evidence

      Live Scholar search

      Cross-database citation index for Phellinus Linteus as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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