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evidence · mechanism · dose
Supplements/Peptide

MOTS-c

Mitochondrial-derived peptide for metabolic regulation.

Healthy Aging

Overview

Mitochondrial-derived peptide for metabolic regulation.

Natural sources
    Common forms

      Mechanism of action

      Activates AMPK and folate-methionine cycle.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves insulin sensitivity

        Moderate evidence

        Potential side effects

        Common
        • · Insufficient human data
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Other notes
            • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            Research only

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Peptide
            MOTS-c
            Amazon
            Wide selection · fast shipping
            Peptide
            MOTS-c
            iHerb
            Global delivery · curated brands
            Peptide
            MOTS-c
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalCell Metab · 2015

            MOTS-c and metabolic homeostasis

            Lee C, et al.

            High-fat diet mice

            Key findings

            Prevented diet-induced obesity and insulin resistance.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: MOTS-c — Improves insulin sensitivity

            Live PubMed search

            Live results for "MOTS-c Improves insulin sensitivity" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching MOTS-c and "Improves insulin sensitivity". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: MOTS-c — randomized controlled trial

            Live PubMed search

            Live results for "MOTS-c randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching MOTS-c and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: MOTS-c — meta-analysis

            Live PubMed search

            Live results for "MOTS-c meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching MOTS-c and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: MOTS-c — pharmacokinetics

            Live PubMed search

            Live results for "MOTS-c pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching MOTS-c and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: MOTS-c — safety adverse events

            Live PubMed search

            Live results for "MOTS-c safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching MOTS-c and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: MOTS-c — dose response

            Live PubMed search

            Live results for "MOTS-c dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching MOTS-c and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: MOTS-c — clinical evidence

            Live Scholar search

            Cross-database citation index for MOTS-c as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.