Overview
Mitochondrial-derived peptide for metabolic regulation.
- Synthetic peptide manufactured to pharmaceutical or research-grade purity
- Subcutaneous injection, sublingual, or oral preparation depending on bioavailability
- Compounded by a licensed pharmacy for clinical use
- Subcutaneous injection
- Oral or sublingual lozenge
- Nasal spray
- Compounded topical
Mechanism of action
Activates AMPK and folate-methionine cycle.
- · Activates AMPK
- · folate-methionine cycle
Effects on the body
Organ system effects
MOTS-c affects hepatic insulin sensitivity, lipid handling, or glucose disposal.
MOTS-c acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Evidence-based benefits
Improves insulin sensitivity
Moderate evidencePotential side effects
- · Insufficient human data
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Most research peptides are not FDA-approved for human use outside investigational protocols.
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified MOTS-c — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.MOTS-c third party tested NSF
CapsulesPre-measured MOTS-c capsules — easiest for travel and consistent daily dosing without scoops or scales.MOTS-c capsules
PowderBulk unflavored MOTS-c powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.MOTS-c powder unflavored
Best sellersMost-purchased MOTS-c products on Amazon — a quick way to see what's reviewed widely before you commit.MOTS-c best sellerScientific evidence8Show studiesHide studies
MOTS-c and metabolic homeostasis
Lee C, et al.
High-fat diet mice
Prevented diet-induced obesity and insulin resistance.
PubMed: MOTS-c — Improves insulin sensitivity
Live PubMed search
Live results for "MOTS-c Improves insulin sensitivity" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching MOTS-c and "Improves insulin sensitivity". Filter by RCT, meta-analysis, or year on the results page.
PubMed: MOTS-c — randomized controlled trial
Live PubMed search
Live results for "MOTS-c randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching MOTS-c and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
PubMed: MOTS-c — meta-analysis
Live PubMed search
Live results for "MOTS-c meta-analysis" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching MOTS-c and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
PubMed: MOTS-c — pharmacokinetics
Live PubMed search
Live results for "MOTS-c pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching MOTS-c and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.
PubMed: MOTS-c — safety adverse events
Live PubMed search
Live results for "MOTS-c safety adverse events" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching MOTS-c and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.
PubMed: MOTS-c — dose response
Live PubMed search
Live results for "MOTS-c dose response" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching MOTS-c and "dose response". Filter by RCT, meta-analysis, or year on the results page.
Google Scholar: MOTS-c — clinical evidence
Live Scholar search
Cross-database citation index for MOTS-c as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.