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evidence · mechanism · dose
Supplements/Mushroom

Agarikon (Fomitopsis officinalis)

Antiviral polypore mushroom.

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Immune Function

Overview

Antiviral polypore mushroom.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Triterpenes with broad antiviral activity.

Pathways
  • · Triterpenes with broad antiviral activity

Effects on the body

Supports
Antiviral (preclinical)

Organ system effects

Immune System

Agarikon (Fomitopsis officinalis) modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Antiviral (preclinical)

Moderate evidence

Potential side effects

Common
  • · Bitter taste
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Agarikon (Fomitopsis officinalis) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with
      • Vitamin D3 + K2
        Foundational immune modulation.
      • Zinc
        Required cofactor for innate and adaptive immune function.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

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      Suggested products
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      Scientific evidence8Show studies
      In vitroMycomedicinals · 2005

      Agarikon antiviral

      Stamets P

      Viral assays

      Key findings

      Activity against pox and influenza viruses.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agarikon (Fomitopsis officinalis) — Antiviral

      Live PubMed search

      Live results for "Agarikon (Fomitopsis officinalis) Antiviral" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agarikon (Fomitopsis officinalis) and "Antiviral". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agarikon (Fomitopsis officinalis) — randomized controlled trial

      Live PubMed search

      Live results for "Agarikon (Fomitopsis officinalis) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agarikon (Fomitopsis officinalis) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agarikon (Fomitopsis officinalis) — meta-analysis

      Live PubMed search

      Live results for "Agarikon (Fomitopsis officinalis) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agarikon (Fomitopsis officinalis) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agarikon (Fomitopsis officinalis) — pharmacokinetics

      Live PubMed search

      Live results for "Agarikon (Fomitopsis officinalis) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agarikon (Fomitopsis officinalis) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agarikon (Fomitopsis officinalis) — safety adverse events

      Live PubMed search

      Live results for "Agarikon (Fomitopsis officinalis) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agarikon (Fomitopsis officinalis) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agarikon (Fomitopsis officinalis) — dose response

      Live PubMed search

      Live results for "Agarikon (Fomitopsis officinalis) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agarikon (Fomitopsis officinalis) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Agarikon (Fomitopsis officinalis) — clinical evidence

      Live Scholar search

      Cross-database citation index for Agarikon (Fomitopsis officinalis) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

      Community discussion

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