Overview
TCM mushroom for sleep and immunity.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Pachymic acid anti-inflammatory.
- · Pachymic acid anti-inflammatory
Effects on the body
Organ system effects
Poria Cocos promotes parasympathetic tone, GABAergic signaling, or melatonergic pathways that facilitate sleep onset and quality.
Poria Cocos modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Sleep support
Moderate evidencePotential side effects
- · Well tolerated
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Autoimmune disease (theoretical immune activation)
- ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)
- ·Immunosuppressants
Supplement interactions
- Magnesium glycinateComplementary GABAergic calming and improved sleep architecture.
- L-theanineReduces sleep latency without sedation.
- Vitamin D3 + K2Foundational immune modulation.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Poria Cocos — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Poria Cocos third party tested NSF
CapsulesPre-measured Poria Cocos capsules — easiest for travel and consistent daily dosing without scoops or scales.Poria Cocos capsules
PowderBulk unflavored Poria Cocos powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Poria Cocos powder unflavored
Best sellersMost-purchased Poria Cocos products on Amazon — a quick way to see what's reviewed widely before you commit.Poria Cocos best sellerScientific evidence8Show studiesHide studies
Poria cocos for insomnia
Lee SM, et al.
30 insomnia patients
Improved sleep parameters.
PubMed: Poria Cocos — Sleep support
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PubMed: Poria Cocos — randomized controlled trial
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PubMed: Poria Cocos — meta-analysis
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PubMed: Poria Cocos — pharmacokinetics
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PubMed: Poria Cocos — safety adverse events
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PubMed: Poria Cocos — dose response
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Google Scholar: Poria Cocos — clinical evidence
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Cross-database citation index for Poria Cocos as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.