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Holy Basil (Tulsi)

Ocimum sanctum adaptogen.

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Overview

Ocimum sanctum adaptogen.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Eugenol and ursolic acid; HPA modulation.

Pathways
  • · Eugenol
  • · ursolic acid
  • · HPA modulation

Effects on the body

Decreases
stress

Organ system effects

Brain & CNS

Holy Basil (Tulsi) modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.

Immune System

Holy Basil (Tulsi) modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Reduces stress

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Holy Basil (Tulsi) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with
      • Vitamin D3 + K2
        Foundational immune modulation.
      • Zinc
        Required cofactor for innate and adaptive immune function.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500 mg standardized
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTEvid Based Complement Alternat Med · 2012

      Tulsi for stress

      Saxena RC, et al.

      158 stressed adults

      Key findings

      Reduced stress symptoms 39%.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil (Tulsi) — Reduces stress

      Live PubMed search

      Live results for "Holy Basil (Tulsi) Reduces stress" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil (Tulsi) and "Reduces stress". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil (Tulsi) — randomized controlled trial

      Live PubMed search

      Live results for "Holy Basil (Tulsi) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil (Tulsi) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil (Tulsi) — meta-analysis

      Live PubMed search

      Live results for "Holy Basil (Tulsi) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil (Tulsi) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil (Tulsi) — pharmacokinetics

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      Live results for "Holy Basil (Tulsi) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil (Tulsi) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil (Tulsi) — safety adverse events

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      Live results for "Holy Basil (Tulsi) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

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      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil (Tulsi) — dose response

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      Live results for "Holy Basil (Tulsi) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil (Tulsi) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Holy Basil (Tulsi) — clinical evidence

      Live Scholar search

      Cross-database citation index for Holy Basil (Tulsi) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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