Overview
Ocimum sanctum adaptogen.
- Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
- Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
- Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
- Standardized extract capsule
- Liquid tincture (alcohol or glycerin)
- Powdered whole herb
- Traditional decoction or tea
Mechanism of action
Eugenol and ursolic acid; HPA modulation.
- · Eugenol
- · ursolic acid
- · HPA modulation
Effects on the body
Organ system effects
Holy Basil (Tulsi) modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.
Holy Basil (Tulsi) modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Reduces stress
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Scientific evidence8Show studiesHide studies
Tulsi for stress
Saxena RC, et al.
158 stressed adults
Reduced stress symptoms 39%.
PubMed: Holy Basil (Tulsi) — Reduces stress
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PubMed: Holy Basil (Tulsi) — randomized controlled trial
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PubMed: Holy Basil (Tulsi) — dose response
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