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evidence · mechanism · dose
Supplements/Compound

Ergothioneine

Unique antioxidant from mushrooms with its own transporter — accumulates in oxidative-stress tissues.

AntioxidantsLongevity PathwaysBrain HealthOxidative Stress

Overview

Unique antioxidant from mushrooms with its own transporter — accumulates in oxidative-stress tissues.

Natural sources
    Common forms

      Forms & variants of Ergothioneine

      Different chemical forms of Ergothioneine behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      High-dose mushroom
      Ergothioneine (Extra)

      Unique thiol antioxidant concentrated in mitochondria via OCTN1.

      Mechanism of action

      Specific transporter (OCTN1) concentrates it in liver, kidney, RBCs, brain; potent ROS scavenger.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lower blood levels associate with cognitive decline

        Limited evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              5–10 mg/d (or mushrooms daily)
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Ergothioneine
              Amazon
              Wide selection · fast shipping
              Compound
              Ergothioneine
              iHerb
              Global delivery · curated brands
              Compound
              Ergothioneine
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              CohortBiochem Biophys Res Commun · 2016

              Ergothioneine status and cognitive decline

              Cheah IK, et al.

              Cohort study of plasma ergothioneine in older adults.

              Key findings

              Lower levels associated with cognitive impairment and frailty.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine — Lower blood levels associate with cognitive decline

              Live PubMed search

              Live results for "Ergothioneine Lower blood levels associate with cognitive decline" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine and "Lower blood levels associate with cognitive decline". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine — randomized controlled trial

              Live PubMed search

              Live results for "Ergothioneine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine — meta-analysis

              Live PubMed search

              Live results for "Ergothioneine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine — pharmacokinetics

              Live PubMed search

              Live results for "Ergothioneine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine — safety adverse events

              Live PubMed search

              Live results for "Ergothioneine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine — dose response

              Live PubMed search

              Live results for "Ergothioneine dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Ergothioneine — clinical evidence

              Live Scholar search

              Cross-database citation index for Ergothioneine as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.