SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

Ergothioneine (Extra)

Unique thiol antioxidant concentrated in mitochondria via OCTN1.

Healthy AgingBrain & Cognitive

Overview

Unique thiol antioxidant concentrated in mitochondria via OCTN1.

Natural sources
    Common forms

      Forms & variants of Ergothioneine

      Different chemical forms of Ergothioneine behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Ergothioneine

      Unique antioxidant from mushrooms with its own transporter — accumulates in oxidative-stress tissues.

      Mechanism of action

      Selective transport into oxidatively stressed cells; scavenges hydroxyl radicals.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Inverse association with cognitive decline

        Limited evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              5–25 mg
              With food?
              Either

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Ergothionein…
              Amazon
              Wide selection · fast shipping
              Compound
              Ergothionein…
              iHerb
              Global delivery · curated brands
              Compound
              Ergothionein…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              CohortHeliyon · 2020

              Ergothioneine and frailty

              Beelman RB, et al.

              Observational study in elderly.

              Key findings

              Low ergothioneine correlated with frailty and cognitive decline.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine (Extra) — Inverse association with cognitive decline

              Live PubMed search

              Live results for "Ergothioneine (Extra) Inverse association with cognitive decline" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine (Extra) and "Inverse association with cognitive decline". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine (Extra) — randomized controlled trial

              Live PubMed search

              Live results for "Ergothioneine (Extra) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine (Extra) — meta-analysis

              Live PubMed search

              Live results for "Ergothioneine (Extra) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine (Extra) — pharmacokinetics

              Live PubMed search

              Live results for "Ergothioneine (Extra) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine (Extra) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine (Extra) — safety adverse events

              Live PubMed search

              Live results for "Ergothioneine (Extra) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine (Extra) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ergothioneine (Extra) — dose response

              Live PubMed search

              Live results for "Ergothioneine (Extra) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ergothioneine (Extra) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Ergothioneine (Extra) — clinical evidence

              Live Scholar search

              Cross-database citation index for Ergothioneine (Extra) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.