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evidence · mechanism · dose
Supplements/Amino Acid

NAC (Lung Support)

Mucolytic and antioxidant — used for COPD exacerbations and idiopathic pulmonary fibrosis.

Lung HealthAntioxidants

Overview

Mucolytic and antioxidant — used for COPD exacerbations and idiopathic pulmonary fibrosis.

Natural sources
    Common forms

      Mechanism of action

      Breaks disulfide bonds in mucus; replenishes pulmonary glutathione.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces COPD exacerbations

        Moderate evidence

        Potential side effects

        Common
        • · Sulfur burps
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            600 mg BID-TID
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTLancet Respir Med · 2014

            NAC in chronic obstructive pulmonary disease (PANTHEON)

            Zheng JP, et al.

            1-year RCT of NAC 600 mg BID in COPD.

            Key findings

            Reduced exacerbation rate by 22%.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: NAC (Lung Support) — Reduces COPD exacerbations

            Live PubMed search

            Live results for "NAC (Lung Support) Reduces COPD exacerbations" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching NAC (Lung Support) and "Reduces COPD exacerbations". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: NAC (Lung Support) — randomized controlled trial

            Live PubMed search

            Live results for "NAC (Lung Support) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching NAC (Lung Support) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: NAC (Lung Support) — meta-analysis

            Live PubMed search

            Live results for "NAC (Lung Support) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching NAC (Lung Support) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: NAC (Lung Support) — pharmacokinetics

            Live PubMed search

            Live results for "NAC (Lung Support) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching NAC (Lung Support) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: NAC (Lung Support) — safety adverse events

            Live PubMed search

            Live results for "NAC (Lung Support) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching NAC (Lung Support) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: NAC (Lung Support) — dose response

            Live PubMed search

            Live results for "NAC (Lung Support) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching NAC (Lung Support) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: NAC (Lung Support) — clinical evidence

            Live Scholar search

            Cross-database citation index for NAC (Lung Support) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.