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evidence · mechanism · dose
Supplements/Amino Acid

L-Lysine

Essential amino acid for collagen and HSV prevention.

Immune FunctionSkin, Hair & Nails

Overview

Essential amino acid for collagen and HSV prevention.

Natural sources
    Common forms

      Mechanism of action

      Antagonizes arginine for HSV replication.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces HSV recurrence

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1000 mg/d

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Amino Acid
            L-Lysine
            Amazon
            Wide selection · fast shipping
            Amino Acid
            L-Lysine
            iHerb
            Global delivery · curated brands
            Amino Acid
            L-Lysine
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTDermatologica · 1987

            Lysine for HSV

            Griffith RS, et al.

            41 HSV patients

            Key findings

            Reduced recurrence rate and severity.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Lysine — Reduces HSV recurrence

            Live PubMed search

            Live results for "L-Lysine Reduces HSV recurrence" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Lysine and "Reduces HSV recurrence". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Lysine — randomized controlled trial

            Live PubMed search

            Live results for "L-Lysine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Lysine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Lysine — meta-analysis

            Live PubMed search

            Live results for "L-Lysine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Lysine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Lysine — pharmacokinetics

            Live PubMed search

            Live results for "L-Lysine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Lysine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Lysine — safety adverse events

            Live PubMed search

            Live results for "L-Lysine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Lysine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Lysine — dose response

            Live PubMed search

            Live results for "L-Lysine dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Lysine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: L-Lysine — clinical evidence

            Live Scholar search

            Cross-database citation index for L-Lysine as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.