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Supplements/Mushroom

Agaricus Blazei

Brazilian sun mushroom for immune support.

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Overview

Brazilian sun mushroom for immune support.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Beta-glucans and ergosterol modulate immunity.

Pathways
  • · Beta-glucans
  • · ergosterol modulate immunity

Effects on the body

Increases
NK cell activity

Organ system effects

Immune System

Agaricus Blazei modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Increases NK cell activity

Moderate evidence

Potential side effects

Common
  • · GI upset
  • · Hepatotoxicity case reports
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Agaricus Blazei use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with
      • Vitamin D3 + K2
        Foundational immune modulation.
      • Zinc
        Required cofactor for innate and adaptive immune function.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      1500 mg extract
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTInt J Gynecol Cancer · 2004

      Agaricus blazei in gynecologic cancers

      Ahn WS, et al.

      100 patients on chemo

      Key findings

      Improved NK activity and quality of life.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agaricus Blazei — Increases NK cell activity

      Live PubMed search

      Live results for "Agaricus Blazei Increases NK cell activity" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agaricus Blazei and "Increases NK cell activity". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agaricus Blazei — randomized controlled trial

      Live PubMed search

      Live results for "Agaricus Blazei randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agaricus Blazei and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agaricus Blazei — meta-analysis

      Live PubMed search

      Live results for "Agaricus Blazei meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agaricus Blazei and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agaricus Blazei — pharmacokinetics

      Live PubMed search

      Live results for "Agaricus Blazei pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agaricus Blazei and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agaricus Blazei — safety adverse events

      Live PubMed search

      Live results for "Agaricus Blazei safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agaricus Blazei and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Agaricus Blazei — dose response

      Live PubMed search

      Live results for "Agaricus Blazei dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Agaricus Blazei and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Agaricus Blazei — clinical evidence

      Live Scholar search

      Cross-database citation index for Agaricus Blazei as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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