Overview
Brazilian mushroom rich in β-glucans for immune modulation.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
β-(1-3)/(1-6)-D-glucans activate Dectin-1 on innate immune cells.
- · β-(1-3)/(1-6)-D-glucans activate Dectin-1 on innate immune cells
Effects on the body
Organ system effects
Agaricus blazei modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Improves QoL during chemotherapy
Moderate evidencePotential side effects
- · Mild GI upset
- · Hepatotoxicity (case reports)
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Agaricus blazei — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Agaricus blazei third party tested NSF
CapsulesPre-measured Agaricus blazei capsules — easiest for travel and consistent daily dosing without scoops or scales.Agaricus blazei capsules
PowderBulk unflavored Agaricus blazei powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Agaricus blazei powder unflavored
Best sellersMost-purchased Agaricus blazei products on Amazon — a quick way to see what's reviewed widely before you commit.Agaricus blazei best sellerScientific evidence8Show studiesHide studies
Agaricus extract during gynecologic chemo
Ahn WS, et al.
Trial in 100 cervical/ovarian/endometrial cancer patients.
Improved NK activity and reduced chemo side effects.
PubMed: Agaricus blazei — Improves QoL during chemotherapy
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PubMed: Agaricus blazei — randomized controlled trial
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