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evidence · mechanism · dose
Supplements/Mushroom

Agaricus blazei

Brazilian mushroom rich in β-glucans for immune modulation.

Immune Function

Overview

Brazilian mushroom rich in β-glucans for immune modulation.

Natural sources
    Common forms

      Mechanism of action

      β-(1-3)/(1-6)-D-glucans activate Dectin-1 on innate immune cells.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves QoL during chemotherapy

        Moderate evidence

        Potential side effects

        Common
        • · Mild GI upset
        Rare
        • · Hepatotoxicity (case reports)
        Serious

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)
          Avoid with these conditions
          • ·Autoimmune disease (theoretical immune activation)
          Avoid / monitor with these medications
          • ·Immunosuppressants

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          1500–3000 mg extract
          With food?
          With food

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Mushroom
          Agaricus bla…
          Amazon
          Wide selection · fast shipping
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          iHerb
          Global delivery · curated brands
          Mushroom
          Agaricus bla…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTInt J Gynecol Cancer · 2004

          Agaricus extract during gynecologic chemo

          Ahn WS, et al.

          Trial in 100 cervical/ovarian/endometrial cancer patients.

          Key findings

          Improved NK activity and reduced chemo side effects.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Agaricus blazei — Improves QoL during chemotherapy

          Live PubMed search

          Live results for "Agaricus blazei Improves QoL during chemotherapy" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Agaricus blazei and "Improves QoL during chemotherapy". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Agaricus blazei — randomized controlled trial

          Live PubMed search

          Live results for "Agaricus blazei randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Agaricus blazei and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Agaricus blazei — meta-analysis

          Live PubMed search

          Live results for "Agaricus blazei meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Agaricus blazei and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Agaricus blazei — pharmacokinetics

          Live PubMed search

          Live results for "Agaricus blazei pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Agaricus blazei and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Agaricus blazei — safety adverse events

          Live PubMed search

          Live results for "Agaricus blazei safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Agaricus blazei and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Agaricus blazei — dose response

          Live PubMed search

          Live results for "Agaricus blazei dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Agaricus blazei and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Agaricus blazei — clinical evidence

          Live Scholar search

          Cross-database citation index for Agaricus blazei as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.