Overview
Gut-derived ellagitannin metabolite that induces mitophagy.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Forms & variants of Urolithin A
Different chemical forms of Urolithin A behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Selectively activates PINK1/Parkin-mediated mitophagy in aged muscle.
- · Selectively activates PINK1/Parkin-mediated mitophagy in aged muscle
Effects on the body
Organ system effects
Urolithin A (Mitopure) acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Urolithin A (Mitopure) influences muscle protein synthesis, neuromuscular output, or recovery from exercise.
Evidence-based benefits
Improves muscle endurance in older adults
Moderate evidencePotential side effects
- · Urolithin A (Mitopure) is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
- Creatine monohydrateFoundational support for strength, power, and lean mass.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Urolithin A (Mitopure) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Urolithin A (Mitopure) third party tested NSF
CapsulesPre-measured Urolithin A (Mitopure) capsules — easiest for travel and consistent daily dosing without scoops or scales.Urolithin A (Mitopure) capsules
PowderBulk unflavored Urolithin A (Mitopure) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Urolithin A (Mitopure) powder unflavored
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Urolithin A in older adults
Singh A, et al.
4-month DB-RCT in 88 older adults.
Improved muscle endurance without exercise.
PubMed: Urolithin A (Mitopure) — Improves muscle endurance in older adults
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