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evidence · mechanism · dose
Supplements/Compound

Urolithin A (Mitopure)

Gut-derived ellagitannin metabolite that induces mitophagy.

Healthy AgingMuscle Growth

Overview

Gut-derived ellagitannin metabolite that induces mitophagy.

Natural sources
    Common forms

      Forms & variants of Urolithin A

      Different chemical forms of Urolithin A behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Urolithin A

      Gut-microbial metabolite of ellagitannins — induces mitophagy.

      Mechanism of action

      Selectively activates PINK1/Parkin-mediated mitophagy in aged muscle.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves muscle endurance in older adults

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              500–1000 mg
              With food?
              With food

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Urolithin A …
              Amazon
              Wide selection · fast shipping
              Compound
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              iHerb
              Global delivery · curated brands
              Compound
              Urolithin A …
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTJAMA Netw Open · 2022

              Urolithin A in older adults

              Singh A, et al.

              4-month DB-RCT in 88 older adults.

              Key findings

              Improved muscle endurance without exercise.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Urolithin A (Mitopure) — Improves muscle endurance in older adults

              Live PubMed search

              Live results for "Urolithin A (Mitopure) Improves muscle endurance in older adults" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Urolithin A (Mitopure) and "Improves muscle endurance in older adults". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Urolithin A (Mitopure) — randomized controlled trial

              Live PubMed search

              Live results for "Urolithin A (Mitopure) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Urolithin A (Mitopure) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Urolithin A (Mitopure) — meta-analysis

              Live PubMed search

              Live results for "Urolithin A (Mitopure) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Urolithin A (Mitopure) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Urolithin A (Mitopure) — pharmacokinetics

              Live PubMed search

              Live results for "Urolithin A (Mitopure) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Urolithin A (Mitopure) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Urolithin A (Mitopure) — safety adverse events

              Live PubMed search

              Live results for "Urolithin A (Mitopure) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Urolithin A (Mitopure) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Urolithin A (Mitopure) — dose response

              Live PubMed search

              Live results for "Urolithin A (Mitopure) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Urolithin A (Mitopure) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Urolithin A (Mitopure) — clinical evidence

              Live Scholar search

              Cross-database citation index for Urolithin A (Mitopure) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.