Overview
Gut-microbial metabolite of ellagitannins — induces mitophagy.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Forms & variants of Urolithin A
Different chemical forms of Urolithin A behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Selectively triggers mitophagy, clearing dysfunctional mitochondria.
- · Selectively triggers mitophagy, clearing dysfunctional mitochondria
Effects on the body
Organ system effects
Urolithin A acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Urolithin A influences muscle protein synthesis, neuromuscular output, or recovery from exercise.
Evidence-based benefits
Improved muscle endurance in older adults
Moderate evidencePotential side effects
- · Urolithin A is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
- Creatine monohydrateFoundational support for strength, power, and lean mass.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Urolithin A — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Urolithin A third party tested NSF
CapsulesPre-measured Urolithin A capsules — easiest for travel and consistent daily dosing without scoops or scales.Urolithin A capsules
PowderBulk unflavored Urolithin A powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Urolithin A powder unflavored
Best sellersMost-purchased Urolithin A products on Amazon — a quick way to see what's reviewed widely before you commit.Urolithin A best sellerScientific evidence8Show studiesHide studies
Urolithin A on mitochondrial and muscle health
Andreux PA, et al.
4-week RCT of Urolithin A in older adults.
Improved mitochondrial gene expression in skeletal muscle.
PubMed: Urolithin A — Improved muscle endurance in older adults
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PubMed: Urolithin A — randomized controlled trial
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PubMed: Urolithin A — meta-analysis
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PubMed: Urolithin A — pharmacokinetics
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PubMed: Urolithin A — safety adverse events
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PubMed: Urolithin A — dose response
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Google Scholar: Urolithin A — clinical evidence
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Cross-database citation index for Urolithin A as it relates to "clinical evidence".
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