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evidence · mechanism · dose
Supplements/Vitamin

Ascorbyl Palmitate

Fat-soluble vitamin C ester.

Skin, Hair & NailsImmune Function

Overview

Fat-soluble vitamin C ester.

Natural sources
    Common forms

      Mechanism of action

      Lipid-soluble vitamin C derivative.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Skin antioxidant

        Moderate evidence

        Potential side effects

        Common
        • · Skin irritation topical
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Vitamin
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            iHerb
            Global delivery · curated brands
            Vitamin
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewDermatol Surg · 2001

            Ascorbyl palmitate skin

            Pinnell SR, et al.

            Mechanistic review

            Key findings

            Topical antioxidant.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ascorbyl Palmitate — Skin antioxidant

            Live PubMed search

            Live results for "Ascorbyl Palmitate Skin antioxidant" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ascorbyl Palmitate and "Skin antioxidant". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ascorbyl Palmitate — randomized controlled trial

            Live PubMed search

            Live results for "Ascorbyl Palmitate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ascorbyl Palmitate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ascorbyl Palmitate — meta-analysis

            Live PubMed search

            Live results for "Ascorbyl Palmitate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ascorbyl Palmitate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ascorbyl Palmitate — pharmacokinetics

            Live PubMed search

            Live results for "Ascorbyl Palmitate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ascorbyl Palmitate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ascorbyl Palmitate — safety adverse events

            Live PubMed search

            Live results for "Ascorbyl Palmitate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ascorbyl Palmitate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ascorbyl Palmitate — dose response

            Live PubMed search

            Live results for "Ascorbyl Palmitate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ascorbyl Palmitate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Ascorbyl Palmitate — clinical evidence

            Live Scholar search

            Cross-database citation index for Ascorbyl Palmitate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.