Overview
Flavonoid studied as senolytic — clearing senescent cells in animal models.
- Strawberries
- Apples
- Persimmons
- Liposomal fisetin
- Plain fisetin
Forms & variants of Fisetin
Different chemical forms of Fisetin behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Selectively induces apoptosis in senescent cells (senolytic).
- · Senolysis
Effects on the body
Organ system effects
Fisetin acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Evidence-based benefits
Senolytic in animal models
Limited evidenceHuman trials underway
Limited evidencePotential side effects
- · Fisetin is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Fisetin — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Fisetin third party tested NSF
CapsulesPre-measured Fisetin capsules — easiest for travel and consistent daily dosing without scoops or scales.Fisetin capsules
PowderBulk unflavored Fisetin powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Fisetin powder unflavored
Best sellersMost-purchased Fisetin products on Amazon — a quick way to see what's reviewed widely before you commit.Fisetin best sellerScientific evidence9Show studiesHide studies
Fisetin as a senolytic in aged mice and humans
Yousefzadeh MJ, et al.
Mouse studies + early human pilots of fisetin.
Reduced senescent-cell markers and extended healthspan in mice.
PubMed: Fisetin — Senolytic in animal models
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PubMed: Fisetin — Human trials underway
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PubMed: Fisetin — randomized controlled trial
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PubMed: Fisetin — meta-analysis
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PubMed: Fisetin — pharmacokinetics
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PubMed: Fisetin — safety adverse events
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PubMed: Fisetin — dose response
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Google Scholar: Fisetin — clinical evidence
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Cross-database citation index for Fisetin as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.