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evidence · mechanism · dose
Supplements/Compound

Fisetin

Flavonoid studied as senolytic — clearing senescent cells in animal models.

Healthy Aging

Overview

Flavonoid studied as senolytic — clearing senescent cells in animal models.

Natural sources
  • Strawberries
  • Apples
  • Persimmons
Common forms
  • Liposomal fisetin
  • Plain fisetin

Forms & variants of Fisetin

Different chemical forms of Fisetin behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Senolytic protocol
Fisetin (Senolytic)

Polyphenol senolytic with neuroprotective and anti-inflammatory effects.

Mechanism of action

Selectively induces apoptosis in senescent cells (senolytic).

Pathways
  • · Senolysis

Effects on the body

Decreases
Senescent cell burden (animal)

Organ system effects

Evidence-based benefits

Senolytic in animal models

Limited evidence

Human trials underway

Limited evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        No notable interactions reported.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        100 mg/d general; 1500 mg × 2 days/month (senolytic protocol)

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        Fisetin
        Amazon
        Wide selection · fast shipping
        Compound
        Fisetin
        iHerb
        Global delivery · curated brands
        Compound
        Fisetin
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (9)

        AnimalEBioMedicine · 2018

        Fisetin as a senolytic in aged mice and humans

        Yousefzadeh MJ, et al.

        Mouse studies + early human pilots of fisetin.

        Key findings

        Reduced senescent-cell markers and extended healthspan in mice.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Fisetin — Senolytic in animal models

        Live PubMed search

        Live results for "Fisetin Senolytic in animal models" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Fisetin and "Senolytic in animal models". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Fisetin — Human trials underway

        Live PubMed search

        Live results for "Fisetin Human trials underway" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Fisetin and "Human trials underway". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Fisetin — randomized controlled trial

        Live PubMed search

        Live results for "Fisetin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Fisetin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Fisetin — meta-analysis

        Live PubMed search

        Live results for "Fisetin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Fisetin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Fisetin — pharmacokinetics

        Live PubMed search

        Live results for "Fisetin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Fisetin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Fisetin — safety adverse events

        Live PubMed search

        Live results for "Fisetin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Fisetin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Fisetin — dose response

        Live PubMed search

        Live results for "Fisetin dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Fisetin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Fisetin — clinical evidence

        Live Scholar search

        Cross-database citation index for Fisetin as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.