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evidence · mechanism · dose
Supplements/Compound

Fisetin (Senolytic)

Polyphenol senolytic with neuroprotective and anti-inflammatory effects.

Healthy AgingBrain & Cognitive

Overview

Polyphenol senolytic with neuroprotective and anti-inflammatory effects.

Natural sources
    Common forms

      Forms & variants of Fisetin

      Different chemical forms of Fisetin behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Fisetin

      Flavonoid studied as senolytic — clearing senescent cells in animal models.

      Parent
      Fisetin

      Flavonoid senolytic — clears senescent cells in animal models.

      Mechanism of action

      Clears senescent cells via Bcl-2 family modulation; activates Nrf2.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces senescent cell burden in animals

        Limited evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            100 mg (daily) or 20 mg/kg pulsed (research)
            With food?
            With fat

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
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            Compound
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalEBioMedicine · 2018

            Fisetin as senolytic in mice

            Yousefzadeh MJ, et al.

            Aged mice treated with fisetin pulses.

            Key findings

            Reduced senescent cell markers and extended median lifespan.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fisetin (Senolytic) — Reduces senescent cell burden in animals

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            Live results for "Fisetin (Senolytic) Reduces senescent cell burden in animals" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Fisetin (Senolytic) and "Reduces senescent cell burden in animals". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fisetin (Senolytic) — randomized controlled trial

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            Live results for "Fisetin (Senolytic) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Fisetin (Senolytic) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fisetin (Senolytic) — meta-analysis

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            Live results for "Fisetin (Senolytic) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Fisetin (Senolytic) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fisetin (Senolytic) — pharmacokinetics

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            Live results for "Fisetin (Senolytic) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fisetin (Senolytic) — safety adverse events

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fisetin (Senolytic) — dose response

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            Live results for "Fisetin (Senolytic) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Fisetin (Senolytic) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Fisetin (Senolytic) — clinical evidence

            Live Scholar search

            Cross-database citation index for Fisetin (Senolytic) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.