Overview
Glycine-chelated zinc — high absorption and very gentle on the stomach.
Forms & variants of Zinc
Different chemical forms of Zinc behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.
Zinc chelated to picolinic acid — one of the most bioavailable oral forms.
Lozenge form shown to shorten cold duration when used at first symptoms.
Most common over-the-counter zinc form — affordable, moderate bioavailability.
Chelated zinc with superior absorption and tolerability.
Mechanism of action
Chelated to two glycines, absorbed via amino acid transporters.
- · Zn enzymes
- · Immune signaling
Effects on the body
Organ system effects
Evidence-based benefits
Equivalent or better absorption vs picolinate, fewer GI complaints
Limited evidencePotential side effects
Drug interactions
No notable interactions reported.
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
None listed.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.
Scientific evidence (8)
Zinc bisglycinate vs gluconate absorption
Gandia P, et al.
Crossover trial in healthy subjects.
Bisglycinate produced higher serum zinc AUC than gluconate.
PubMed: Zinc Bisglycinate — Equivalent or better absorption vs picolinate, fewer GI complaints
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PubMed: Zinc Bisglycinate — randomized controlled trial
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PubMed: Zinc Bisglycinate — meta-analysis
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PubMed: Zinc Bisglycinate — pharmacokinetics
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PubMed: Zinc Bisglycinate — safety adverse events
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PubMed: Zinc Bisglycinate — dose response
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Google Scholar: Zinc Bisglycinate — clinical evidence
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