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evidence · mechanism · dose
Supplements/Mineral

Zinc Bisglycinate (High-Bio)

Chelated zinc with superior absorption and tolerability.

Immune FunctionSkin, Hair & NailsGeneral Wellness

Overview

Chelated zinc with superior absorption and tolerability.

Natural sources
    Common forms

      Forms & variants of Zinc

      Different chemical forms of Zinc behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Zinc

      Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.

      Picolinate
      Zinc Picolinate

      Zinc chelated to picolinic acid — one of the most bioavailable oral forms.

      Bisglycinate
      Zinc Bisglycinate

      Glycine-chelated zinc — high absorption and very gentle on the stomach.

      Acetate (lozenges)
      Zinc Acetate

      Lozenge form shown to shorten cold duration when used at first symptoms.

      Gluconate
      Zinc Gluconate

      Most common over-the-counter zinc form — affordable, moderate bioavailability.

      Mechanism of action

      Glycine chelate bypasses competition with calcium and iron in the gut.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Higher serum zinc rise than zinc gluconate

        Moderate evidence

        Potential side effects

        Common
        • · Nausea (less than other forms)
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            15–30 mg elemental
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Mineral
            Zinc Bisglyc…
            Amazon
            Wide selection · fast shipping
            Mineral
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            iHerb
            Global delivery · curated brands
            Mineral
            Zinc Bisglyc…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTInt J Vitam Nutr Res · 2007

            Zinc bisglycinate vs gluconate absorption

            Gandia P, et al.

            Crossover PK study in healthy adults.

            Key findings

            Bisglycinate showed 43% higher AUC than gluconate.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Bisglycinate (High-Bio) — Higher serum zinc rise than zinc gluconate

            Live PubMed search

            Live results for "Zinc Bisglycinate (High-Bio) Higher serum zinc rise than zinc gluconate" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Bisglycinate (High-Bio) and "Higher serum zinc rise than zinc gluconate". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Bisglycinate (High-Bio) — randomized controlled trial

            Live PubMed search

            Live results for "Zinc Bisglycinate (High-Bio) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Bisglycinate (High-Bio) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Bisglycinate (High-Bio) — meta-analysis

            Live PubMed search

            Live results for "Zinc Bisglycinate (High-Bio) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Bisglycinate (High-Bio) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Bisglycinate (High-Bio) — pharmacokinetics

            Live PubMed search

            Live results for "Zinc Bisglycinate (High-Bio) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Bisglycinate (High-Bio) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Bisglycinate (High-Bio) — safety adverse events

            Live PubMed search

            Live results for "Zinc Bisglycinate (High-Bio) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Bisglycinate (High-Bio) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Bisglycinate (High-Bio) — dose response

            Live PubMed search

            Live results for "Zinc Bisglycinate (High-Bio) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Bisglycinate (High-Bio) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Zinc Bisglycinate (High-Bio) — clinical evidence

            Live Scholar search

            Cross-database citation index for Zinc Bisglycinate (High-Bio) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.