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evidence · mechanism · dose
Supplements/Compound

Lutein & Zeaxanthin

Macular carotenoids that filter blue light and reduce AMD progression.

Eye Health

Overview

Macular carotenoids that filter blue light and reduce AMD progression.

Natural sources
  • Marigold
  • Egg yolk
  • Kale
  • Spinach
Common forms
  • FloraGlo lutein + zeaxanthin

Forms & variants of Lutein & Zeaxanthin

Different chemical forms of Lutein & Zeaxanthin behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Meso-zeaxanthin
Meso-Zeaxanthin

Central macular carotenoid not present in typical diet.

Mechanism of action

Concentrate in macula filtering blue light and quenching ROS.

Pathways
  • · Macular pigment density

Effects on the body

Supports
Macular pigment density

Organ system effects

Eye

Slows AMD progression (AREDS2).

Evidence-based benefits

Reduces AMD progression (AREDS2)

Strong evidence

Improves contrast sensitivity

Moderate evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        No notable interactions reported.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        10 mg lutein + 2 mg zeaxanthin

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        Lutein & Zea…
        Amazon
        Wide selection · fast shipping
        Compound
        Lutein & Zea…
        iHerb
        Global delivery · curated brands
        Compound
        Lutein & Zea…
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (9)

        RCTJAMA · 2013

        AREDS2 — lutein/zeaxanthin for age-related macular degeneration

        AREDS2 Research Group

        5-year RCT of L/Z replacing beta-carotene in AREDS formula.

        Key findings

        Reduced AMD progression in low-dietary-L/Z participants.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lutein & Zeaxanthin — Reduces AMD progression

        Live PubMed search

        Live results for "Lutein & Zeaxanthin Reduces AMD progression" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lutein & Zeaxanthin and "Reduces AMD progression". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lutein & Zeaxanthin — Improves contrast sensitivity

        Live PubMed search

        Live results for "Lutein & Zeaxanthin Improves contrast sensitivity" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lutein & Zeaxanthin and "Improves contrast sensitivity". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lutein & Zeaxanthin — randomized controlled trial

        Live PubMed search

        Live results for "Lutein & Zeaxanthin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lutein & Zeaxanthin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lutein & Zeaxanthin — meta-analysis

        Live PubMed search

        Live results for "Lutein & Zeaxanthin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lutein & Zeaxanthin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lutein & Zeaxanthin — pharmacokinetics

        Live PubMed search

        Live results for "Lutein & Zeaxanthin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lutein & Zeaxanthin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lutein & Zeaxanthin — safety adverse events

        Live PubMed search

        Live results for "Lutein & Zeaxanthin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lutein & Zeaxanthin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lutein & Zeaxanthin — dose response

        Live PubMed search

        Live results for "Lutein & Zeaxanthin dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lutein & Zeaxanthin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Lutein & Zeaxanthin — clinical evidence

        Live Scholar search

        Cross-database citation index for Lutein & Zeaxanthin as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.