Overview
Urtica dioica leaf for allergies and joint pain.
- Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
- Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
- Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
- Standardized extract capsule
- Liquid tincture (alcohol or glycerin)
- Powdered whole herb
- Traditional decoction or tea
Mechanism of action
Inhibits histamine; modulates NF-κB.
- · Inhibits histamine
- · modulates NF-κB
Effects on the body
Organ system effects
Stinging Nettle Leaf modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Reduces allergic rhinitis
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Stinging Nettle Leaf — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Stinging Nettle Leaf third party tested NSF
CapsulesPre-measured Stinging Nettle Leaf capsules — easiest for travel and consistent daily dosing without scoops or scales.Stinging Nettle Leaf capsules
PowderBulk unflavored Stinging Nettle Leaf powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Stinging Nettle Leaf powder unflavored
Best sellersMost-purchased Stinging Nettle Leaf products on Amazon — a quick way to see what's reviewed widely before you commit.Stinging Nettle Leaf best sellerScientific evidence8Show studiesHide studies
Nettle for allergic rhinitis
Mittman P
69 patients
Better than placebo for symptom relief.
PubMed: Stinging Nettle Leaf — Reduces allergic rhinitis
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