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evidence · mechanism · dose
Supplements/Herb

Stinging Nettle Leaf

Urtica dioica leaf for allergies and joint pain.

Immune Function

Overview

Urtica dioica leaf for allergies and joint pain.

Natural sources
    Common forms

      Mechanism of action

      Inhibits histamine; modulates NF-κB.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces allergic rhinitis

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300 mg freeze-dried

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Stinging Net…
            Amazon
            Wide selection · fast shipping
            Herb
            Stinging Net…
            iHerb
            Global delivery · curated brands
            Herb
            Stinging Net…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPlanta Med · 1990

            Nettle for allergic rhinitis

            Mittman P

            69 patients

            Key findings

            Better than placebo for symptom relief.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Stinging Nettle Leaf — Reduces allergic rhinitis

            Live PubMed search

            Live results for "Stinging Nettle Leaf Reduces allergic rhinitis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Stinging Nettle Leaf and "Reduces allergic rhinitis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Stinging Nettle Leaf — randomized controlled trial

            Live PubMed search

            Live results for "Stinging Nettle Leaf randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Stinging Nettle Leaf and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Stinging Nettle Leaf — meta-analysis

            Live PubMed search

            Live results for "Stinging Nettle Leaf meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Stinging Nettle Leaf and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Stinging Nettle Leaf — pharmacokinetics

            Live PubMed search

            Live results for "Stinging Nettle Leaf pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Stinging Nettle Leaf and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Stinging Nettle Leaf — safety adverse events

            Live PubMed search

            Live results for "Stinging Nettle Leaf safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Stinging Nettle Leaf and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Stinging Nettle Leaf — dose response

            Live PubMed search

            Live results for "Stinging Nettle Leaf dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Stinging Nettle Leaf and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Stinging Nettle Leaf — clinical evidence

            Live Scholar search

            Cross-database citation index for Stinging Nettle Leaf as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.