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Supplements/Compound

EGCG (Green Tea Catechin)

Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.

Pre-Drug Use SupportPost-Drug Use RecoveryHealthy Aging

Overview

Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.

Natural sources
    Common forms

      Mechanism of action

      Inhibits CYP2D6 (caution with substrate drugs) and serves as a strong antioxidant; binds and inactivates quinone metabolites.

      Pathways
      • · CYP2D6 inhibition
      • · Antioxidant
      • · MAO modulation

      Effects on the body

      Organ system effects

      Evidence-based benefits

      Reduces oxidative stress from amphetamine-class metabolites (in vitro/animal)

      Limited evidence

      Potential side effects

      Common
        Rare
        • · Liver enzyme elevation at >800 mg EGCG/d
        Serious
        • · Hepatotoxicity (rare, dose-related)

        Drug interactions

        CYP2D6 substrates
        Inhibits CYP2D6 — may unpredictably raise levels.
        moderate
        Anticoagulants
        Antiplatelet effect.
        moderate

        Safety & non-supplemental interactions

        Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

        Other notes
        • ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        200–400 mg EGCG before/after; do not exceed 800 mg/d
        With food?
        With food (reduces hepatotox risk)

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        EGCG (Green …
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        iHerb
        Global delivery · curated brands
        Compound
        EGCG (Green …
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        AnimalJ Pharmacol Exp Ther · 2010

        EGCG and MDMA neurotoxicity in animal models

        Touriño C, et al.

        Animal study of EGCG pretreatment before MDMA.

        Key findings

        Reduced MDMA-induced hyperthermia and serotonergic neurotoxicity.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: EGCG (Green Tea Catechin) — Reduces oxidative stress from amphetamine-class metabolites

        Live PubMed search

        Live results for "EGCG (Green Tea Catechin) Reduces oxidative stress from amphetamine-class metabolites" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching EGCG (Green Tea Catechin) and "Reduces oxidative stress from amphetamine-class metabolites". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: EGCG (Green Tea Catechin) — randomized controlled trial

        Live PubMed search

        Live results for "EGCG (Green Tea Catechin) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching EGCG (Green Tea Catechin) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: EGCG (Green Tea Catechin) — meta-analysis

        Live PubMed search

        Live results for "EGCG (Green Tea Catechin) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching EGCG (Green Tea Catechin) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: EGCG (Green Tea Catechin) — pharmacokinetics

        Live PubMed search

        Live results for "EGCG (Green Tea Catechin) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching EGCG (Green Tea Catechin) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: EGCG (Green Tea Catechin) — safety adverse events

        Live PubMed search

        Live results for "EGCG (Green Tea Catechin) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching EGCG (Green Tea Catechin) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: EGCG (Green Tea Catechin) — dose response

        Live PubMed search

        Live results for "EGCG (Green Tea Catechin) dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching EGCG (Green Tea Catechin) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: EGCG (Green Tea Catechin) — clinical evidence

        Live Scholar search

        Cross-database citation index for EGCG (Green Tea Catechin) as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.