Overview
Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Inhibits CYP2D6 (caution with substrate drugs) and serves as a strong antioxidant; binds and inactivates quinone metabolites.
- · CYP2D6 inhibition
- · Antioxidant
- · MAO modulation
Effects on the body
Organ system effects
EGCG (Green Tea Catechin) acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Evidence-based benefits
Reduces oxidative stress from amphetamine-class metabolites (in vitro/animal)
Limited evidencePotential side effects
- · Liver enzyme elevation at >800 mg EGCG/d
- · Hepatotoxicity (rare, dose-related)
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified EGCG (Green Tea Catechin) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.EGCG (Green Tea Catechin) third party tested NSF
CapsulesPre-measured EGCG (Green Tea Catechin) capsules — easiest for travel and consistent daily dosing without scoops or scales.EGCG (Green Tea Catechin) capsules
PowderBulk unflavored EGCG (Green Tea Catechin) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.EGCG (Green Tea Catechin) powder unflavored
Best sellersMost-purchased EGCG (Green Tea Catechin) products on Amazon — a quick way to see what's reviewed widely before you commit.EGCG (Green Tea Catechin) best sellerScientific evidence8Show studiesHide studies
EGCG and MDMA neurotoxicity in animal models
Touriño C, et al.
Animal study of EGCG pretreatment before MDMA.
Reduced MDMA-induced hyperthermia and serotonergic neurotoxicity.
PubMed: EGCG (Green Tea Catechin) — Reduces oxidative stress from amphetamine-class metabolites
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