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Supplements/Peptide

Epitalon

Tetrapeptide that activates telomerase.

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Overview

Tetrapeptide that activates telomerase.

Natural sources
  • Synthetic peptide manufactured to pharmaceutical or research-grade purity
  • Subcutaneous injection, sublingual, or oral preparation depending on bioavailability
  • Compounded by a licensed pharmacy for clinical use
Common forms
  • Subcutaneous injection
  • Oral or sublingual lozenge
  • Nasal spray
  • Compounded topical

Mechanism of action

Activates telomerase reverse transcriptase, lengthens telomeres in vitro.

Pathways
  • · Activates telomerase reverse transcriptase, lengthens telomeres in vitro

Effects on the body

Supports
Anti-aging effects (preclinical)

Organ system effects

Brain & CNS

Epitalon acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.

Evidence-based benefits

Anti-aging effects (preclinical)

Moderate evidence

Potential side effects

Common
  • · Injection site pain
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Epitalon use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Other notes
      • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

      Supplement interactions

      Pairs well with
      • NAD+ precursor (NMN or NR)
        Complementary mitochondrial and sirtuin support.
      • Omega-3
        Lowers inflammation and supports membrane integrity.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      5–10 mg cycled
      Best form
      Most evidence is based on the subcutaneous injection form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      In vitroBull Exp Biol Med · 2003

      Epithalon and telomerase

      Khavinson VK, et al.

      Human fibroblasts

      Key findings

      Increased telomerase activity and telomere length.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Epitalon — Anti-aging effects

      Live PubMed search

      Live results for "Epitalon Anti-aging effects" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Epitalon and "Anti-aging effects". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Epitalon — randomized controlled trial

      Live PubMed search

      Live results for "Epitalon randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Epitalon and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Epitalon — meta-analysis

      Live PubMed search

      Live results for "Epitalon meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Epitalon and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Epitalon — pharmacokinetics

      Live PubMed search

      Live results for "Epitalon pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Epitalon and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Epitalon — safety adverse events

      Live PubMed search

      Live results for "Epitalon safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Epitalon and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Epitalon — dose response

      Live PubMed search

      Live results for "Epitalon dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Epitalon and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Epitalon — clinical evidence

      Live Scholar search

      Cross-database citation index for Epitalon as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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