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Supplements/Fatty Acid

Black Cumin Seed Oil

Nigella sativa oil.

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Overview

Nigella sativa oil.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Thymoquinone-rich.

Pathways
  • · Thymoquinone-rich

Effects on the body

Supports
Multiple health benefits

Organ system effects

Immune System

Black Cumin Seed Oil modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Liver

Black Cumin Seed Oil affects hepatic insulin sensitivity, lipid handling, or glucose disposal.

Evidence-based benefits

Multiple health benefits

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Black Cumin Seed Oil use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with
      • Vitamin D3 + K2
        Foundational immune modulation.
      • Zinc
        Required cofactor for innate and adaptive immune function.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      2–5 mL
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      Meta-analysisFood Res Int · 2015

      Black cumin oil RCT

      Heshmati J, et al.

      17 RCTs

      Key findings

      Improved lipids and glucose.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Black Cumin Seed Oil — Multiple health benefits

      Live PubMed search

      Live results for "Black Cumin Seed Oil Multiple health benefits" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Black Cumin Seed Oil and "Multiple health benefits". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Black Cumin Seed Oil — randomized controlled trial

      Live PubMed search

      Live results for "Black Cumin Seed Oil randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Black Cumin Seed Oil and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Black Cumin Seed Oil — meta-analysis

      Live PubMed search

      Live results for "Black Cumin Seed Oil meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Black Cumin Seed Oil and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Black Cumin Seed Oil — pharmacokinetics

      Live PubMed search

      Live results for "Black Cumin Seed Oil pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Black Cumin Seed Oil and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Black Cumin Seed Oil — safety adverse events

      Live PubMed search

      Live results for "Black Cumin Seed Oil safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Black Cumin Seed Oil and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Black Cumin Seed Oil — dose response

      Live PubMed search

      Live results for "Black Cumin Seed Oil dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Black Cumin Seed Oil and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Black Cumin Seed Oil — clinical evidence

      Live Scholar search

      Cross-database citation index for Black Cumin Seed Oil as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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