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evidence · mechanism · dose
Supplements/Compound

Spermidine (Wheat Germ)

Polyamine that induces autophagy and may extend lifespan.

Healthy AgingBrain & Cognitive

Overview

Polyamine that induces autophagy and may extend lifespan.

Natural sources
    Common forms

      Forms & variants of Spermidine

      Different chemical forms of Spermidine behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Spermidine

      Polyamine inducing autophagy; epidemiologic association with longevity.

      Parent
      Spermidine

      Polyamine that induces autophagy — emerging longevity supplement.

      Mechanism of action

      Autophagy induction via inhibition of EP300; protein hypoacetylation.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves memory in adults with subjective decline

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              1–6 mg/day
              With food?
              Either

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Spermidine (…
              Amazon
              Wide selection · fast shipping
              Compound
              Spermidine (…
              iHerb
              Global delivery · curated brands
              Compound
              Spermidine (…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTCortex · 2018

              Spermidine for memory (SmartAge)

              Wirth M, et al.

              3-month DB-RCT in 28 older adults.

              Key findings

              Improved memory performance vs placebo.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Spermidine (Wheat Germ) — Improves memory in adults with subjective decline

              Live PubMed search

              Live results for "Spermidine (Wheat Germ) Improves memory in adults with subjective decline" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Spermidine (Wheat Germ) and "Improves memory in adults with subjective decline". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Spermidine (Wheat Germ) — randomized controlled trial

              Live PubMed search

              Live results for "Spermidine (Wheat Germ) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Spermidine (Wheat Germ) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Spermidine (Wheat Germ) — meta-analysis

              Live PubMed search

              Live results for "Spermidine (Wheat Germ) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Spermidine (Wheat Germ) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Spermidine (Wheat Germ) — pharmacokinetics

              Live PubMed search

              Live results for "Spermidine (Wheat Germ) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Spermidine (Wheat Germ) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Spermidine (Wheat Germ) — safety adverse events

              Live PubMed search

              Live results for "Spermidine (Wheat Germ) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Spermidine (Wheat Germ) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Spermidine (Wheat Germ) — dose response

              Live PubMed search

              Live results for "Spermidine (Wheat Germ) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Spermidine (Wheat Germ) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Spermidine (Wheat Germ) — clinical evidence

              Live Scholar search

              Cross-database citation index for Spermidine (Wheat Germ) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.