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evidence · mechanism · dose
Supplements/Compound

Spermidine

Polyamine inducing autophagy; epidemiologic association with longevity.

Healthy Aging

Overview

Polyamine inducing autophagy; epidemiologic association with longevity.

Natural sources
  • Wheat germ
  • Aged cheese
  • Soybeans
  • Mushrooms
Common forms
  • Wheat germ extract

Forms & variants of Spermidine

Different chemical forms of Spermidine behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Wheat-germ standardized
Spermidine (Wheat Germ)

Polyamine that induces autophagy and may extend lifespan.

Mechanism of action

Induces autophagy via inhibition of EP300 acetyltransferase.

Pathways
  • · Autophagy induction

Effects on the body

Supports
Autophagy

Organ system effects

Brain & CNS

Linked to lower dementia risk in cohort studies.

Evidence-based benefits

Cohort data suggest reduced mortality and dementia risk

Limited evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        No notable interactions reported.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        1–6 mg/d (wheat germ extract)

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        Spermidine
        Amazon
        Wide selection · fast shipping
        Compound
        Spermidine
        iHerb
        Global delivery · curated brands
        Compound
        Spermidine
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        RCTCortex · 2018

        Spermidine and cognitive function in older adults

        Schwarz C, et al.

        3-month RCT of spermidine-rich wheat germ.

        Key findings

        Improved memory performance in subjective cognitive decline.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Spermidine — Cohort data suggest reduced mortality and dementia risk

        Live PubMed search

        Live results for "Spermidine Cohort data suggest reduced mortality and dementia risk" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Spermidine and "Cohort data suggest reduced mortality and dementia risk". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Spermidine — randomized controlled trial

        Live PubMed search

        Live results for "Spermidine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Spermidine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Spermidine — meta-analysis

        Live PubMed search

        Live results for "Spermidine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Spermidine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Spermidine — pharmacokinetics

        Live PubMed search

        Live results for "Spermidine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Spermidine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Spermidine — safety adverse events

        Live PubMed search

        Live results for "Spermidine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Spermidine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Spermidine — dose response

        Live PubMed search

        Live results for "Spermidine dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Spermidine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Spermidine — clinical evidence

        Live Scholar search

        Cross-database citation index for Spermidine as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.