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evidence · mechanism · dose
Supplements/Compound

Rapamycin

mTOR inhibitor studied for longevity (Rx only).

Healthy Aging

Overview

mTOR inhibitor studied for longevity (Rx only).

Natural sources
    Common forms

      Mechanism of action

      Inhibits mTORC1; promotes autophagy.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Extends lifespan in mice

        Moderate evidence

        Potential side effects

        Common
        • · Mouth ulcers
        • · Hyperlipidemia
        • · Immunosuppression
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            5 mg weekly (off-label)

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Rapamycin
            Amazon
            Wide selection · fast shipping
            Compound
            Rapamycin
            iHerb
            Global delivery · curated brands
            Compound
            Rapamycin
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalNature · 2009

            Rapamycin and lifespan in mice

            Harrison DE, et al.

            Genetically heterogeneous mice

            Key findings

            Extended median lifespan in both sexes.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rapamycin — Extends lifespan in mice

            Live PubMed search

            Live results for "Rapamycin Extends lifespan in mice" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rapamycin and "Extends lifespan in mice". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rapamycin — randomized controlled trial

            Live PubMed search

            Live results for "Rapamycin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rapamycin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rapamycin — meta-analysis

            Live PubMed search

            Live results for "Rapamycin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rapamycin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rapamycin — pharmacokinetics

            Live PubMed search

            Live results for "Rapamycin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rapamycin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rapamycin — safety adverse events

            Live PubMed search

            Live results for "Rapamycin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rapamycin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rapamycin — dose response

            Live PubMed search

            Live results for "Rapamycin dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rapamycin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Rapamycin — clinical evidence

            Live Scholar search

            Cross-database citation index for Rapamycin as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.