Overview
mTOR inhibitor studied for longevity (Rx only).
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Inhibits mTORC1; promotes autophagy.
- · Inhibits mTORC1
- · promotes autophagy
Effects on the body
Organ system effects
Rapamycin acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Evidence-based benefits
Extends lifespan in mice
Moderate evidencePotential side effects
- · Mouth ulcers
- · Hyperlipidemia
- · Immunosuppression
Drug interactions
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Rapamycin — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Rapamycin third party tested NSF
CapsulesPre-measured Rapamycin capsules — easiest for travel and consistent daily dosing without scoops or scales.Rapamycin capsules
PowderBulk unflavored Rapamycin powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Rapamycin powder unflavored
Best sellersMost-purchased Rapamycin products on Amazon — a quick way to see what's reviewed widely before you commit.Rapamycin best sellerScientific evidence8Show studiesHide studies
Rapamycin and lifespan in mice
Harrison DE, et al.
Genetically heterogeneous mice
Extended median lifespan in both sexes.
PubMed: Rapamycin — Extends lifespan in mice
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Google Scholar: Rapamycin — clinical evidence
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