SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Vitamin

Tocotrienols (Skin/Aging)

Vitamin E isoforms with 40–60× higher antioxidant power than tocopherols.

Skin, Hair & NailsHealthy Aging

Overview

Vitamin E isoforms with 40–60× higher antioxidant power than tocopherols.

Natural sources
    Common forms

      Forms & variants of Tocotrienols (Vitamin E)

      Different chemical forms of Tocotrienols (Vitamin E) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Tocotrienols
      Tocotrienols (Vitamin E)

      Unsaturated vitamin E family — superior antioxidant capacity vs alpha-tocopherol.

      Mechanism of action

      Suppresses HMG-CoA reductase, inhibits NF-κB, and protects neurons from glutamate toxicity.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces NAFLD severity

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              150–300 mg annatto tocotrienols
              With food?
              With fat

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Vitamin
              Tocotrienols…
              Amazon
              Wide selection · fast shipping
              Vitamin
              Tocotrienols…
              iHerb
              Global delivery · curated brands
              Vitamin
              Tocotrienols…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTNutr J · 2013

              Tocotrienols in NAFLD

              Magosso E, et al.

              12-month DB-RCT in 87 NAFLD patients.

              Key findings

              Significantly improved liver steatosis on ultrasound.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Tocotrienols (Skin/Aging) — Reduces NAFLD severity

              Live PubMed search

              Live results for "Tocotrienols (Skin/Aging) Reduces NAFLD severity" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Tocotrienols (Skin/Aging) and "Reduces NAFLD severity". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Tocotrienols (Skin/Aging) — randomized controlled trial

              Live PubMed search

              Live results for "Tocotrienols (Skin/Aging) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Tocotrienols (Skin/Aging) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Tocotrienols (Skin/Aging) — meta-analysis

              Live PubMed search

              Live results for "Tocotrienols (Skin/Aging) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Tocotrienols (Skin/Aging) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Tocotrienols (Skin/Aging) — pharmacokinetics

              Live PubMed search

              Live results for "Tocotrienols (Skin/Aging) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Tocotrienols (Skin/Aging) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Tocotrienols (Skin/Aging) — safety adverse events

              Live PubMed search

              Live results for "Tocotrienols (Skin/Aging) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Tocotrienols (Skin/Aging) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Tocotrienols (Skin/Aging) — dose response

              Live PubMed search

              Live results for "Tocotrienols (Skin/Aging) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Tocotrienols (Skin/Aging) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Tocotrienols (Skin/Aging) — clinical evidence

              Live Scholar search

              Cross-database citation index for Tocotrienols (Skin/Aging) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.