SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Amino Acid

L-Carnosine

Histidine dipeptide — anti-glycation and pH buffering.

Longevity PathwaysDNA ProtectionAntioxidantsAthletic Performance

Overview

Histidine dipeptide — anti-glycation and pH buffering.

Natural sources
    Common forms

      Mechanism of action

      Buffers H+ in muscle (β-alanine precursor); chelates metals; reduces AGE formation.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces AGE formation in vitro

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              500–1000 mg
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Amino Acid
              L-Carnosine
              Amazon
              Wide selection · fast shipping
              Amino Acid
              L-Carnosine
              iHerb
              Global delivery · curated brands
              Amino Acid
              L-Carnosine
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTNutr Res · 2018

              Carnosine on glycation and metabolic markers

              Houjeghani S, et al.

              12-week RCT of carnosine 1 g/d in T2D.

              Key findings

              Reduced fasting glucose, HbA1c, and TNF-α.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Carnosine — Reduces AGE formation in vitro

              Live PubMed search

              Live results for "L-Carnosine Reduces AGE formation in vitro" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Carnosine and "Reduces AGE formation in vitro". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Carnosine — randomized controlled trial

              Live PubMed search

              Live results for "L-Carnosine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Carnosine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Carnosine — meta-analysis

              Live PubMed search

              Live results for "L-Carnosine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Carnosine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Carnosine — pharmacokinetics

              Live PubMed search

              Live results for "L-Carnosine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Carnosine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Carnosine — safety adverse events

              Live PubMed search

              Live results for "L-Carnosine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Carnosine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Carnosine — dose response

              Live PubMed search

              Live results for "L-Carnosine dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Carnosine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: L-Carnosine — clinical evidence

              Live Scholar search

              Cross-database citation index for L-Carnosine as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.