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Supplements/Compound

Holy Basil Eugenol

Active constituent of tulsi.

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Overview

Active constituent of tulsi.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

COX inhibitor; antimicrobial.

Pathways
  • · COX inhibitor
  • · antimicrobial

Effects on the body

Supports
Pain and infection

Organ system effects

Immune System

Holy Basil Eugenol modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Pain and infection

Moderate evidence

Potential side effects

Common
  • · Hepatic at high dose
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Holy Basil Eugenol use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with
      • Vitamin D3 + K2
        Foundational immune modulation.
      • Zinc
        Required cofactor for innate and adaptive immune function.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      Topical or 100 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      Systematic reviewNat Prod Commun · 2010

      Eugenol pharmacology

      Pramod K, et al.

      Mechanistic review

      Key findings

      Multiple pharmacological effects.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil Eugenol — Pain and infection

      Live PubMed search

      Live results for "Holy Basil Eugenol Pain and infection" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil Eugenol and "Pain and infection". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil Eugenol — randomized controlled trial

      Live PubMed search

      Live results for "Holy Basil Eugenol randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil Eugenol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil Eugenol — meta-analysis

      Live PubMed search

      Live results for "Holy Basil Eugenol meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil Eugenol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil Eugenol — pharmacokinetics

      Live PubMed search

      Live results for "Holy Basil Eugenol pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil Eugenol and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil Eugenol — safety adverse events

      Live PubMed search

      Live results for "Holy Basil Eugenol safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil Eugenol and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Holy Basil Eugenol — dose response

      Live PubMed search

      Live results for "Holy Basil Eugenol dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Holy Basil Eugenol and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Holy Basil Eugenol — clinical evidence

      Live Scholar search

      Cross-database citation index for Holy Basil Eugenol as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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