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evidence · mechanism · dose
Supplements/Herb

Chinese Skullcap

aka Scutellaria baicalensis · Baicalin

Flavonoid-rich root used for anxiety and inflammation.

Mood & AnxietyImmune Function

Overview

Flavonoid-rich root used for anxiety and inflammation.

Natural sources
    Common forms

      Mechanism of action

      Baicalin acts as positive allosteric modulator at GABA-A benzodiazepine site.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces acute anxiety in small trials

        Limited evidence

        Potential side effects

        Common
        • · Drowsiness
        Rare
        • · Hepatotoxicity (case reports with combination products)
        Serious

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)
          Avoid with these conditions
          • ·Autoimmune disease (theoretical immune activation)
          Avoid / monitor with these medications
          • ·Immunosuppressants

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          350–500 mg standardized extract
          With food?
          With food

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Herb
          Chinese Skul…
          Amazon
          Wide selection · fast shipping
          Herb
          Chinese Skul…
          iHerb
          Global delivery · curated brands
          Herb
          Chinese Skul…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTPhytother Res · 2014

          Scutellaria for anxiety

          Brock C, et al.

          DB-RCT in 31 healthy adults.

          Key findings

          Acute anxiolytic effect of 1050 mg dried root extract.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chinese Skullcap — Reduces acute anxiety in small trials

          Live PubMed search

          Live results for "Chinese Skullcap Reduces acute anxiety in small trials" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chinese Skullcap and "Reduces acute anxiety in small trials". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chinese Skullcap — randomized controlled trial

          Live PubMed search

          Live results for "Chinese Skullcap randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chinese Skullcap and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chinese Skullcap — meta-analysis

          Live PubMed search

          Live results for "Chinese Skullcap meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chinese Skullcap and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chinese Skullcap — pharmacokinetics

          Live PubMed search

          Live results for "Chinese Skullcap pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chinese Skullcap and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chinese Skullcap — safety adverse events

          Live PubMed search

          Live results for "Chinese Skullcap safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chinese Skullcap and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chinese Skullcap — dose response

          Live PubMed search

          Live results for "Chinese Skullcap dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chinese Skullcap and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Chinese Skullcap — clinical evidence

          Live Scholar search

          Cross-database citation index for Chinese Skullcap as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.