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evidence · mechanism · dose
Supplements/Compound

Metformin (Longevity Use)

Biguanide diabetes drug studied for healthspan.

Healthy Aging

Overview

Biguanide diabetes drug studied for healthspan.

Natural sources
    Common forms

      Mechanism of action

      Inhibits mitochondrial complex I; activates AMPK.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        May reduce age-related diseases

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        • · B12 deficiency
        • · Lactic acidosis (rare)
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–1500 mg (Rx only)

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Metformin (L…
            Amazon
            Wide selection · fast shipping
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            iHerb
            Global delivery · curated brands
            Compound
            Metformin (L…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            CohortDiabetes Obes Metab · 2014

            Metformin in non-diabetics (TAME-related)

            Bannister CA, et al.

            78,000+ adults

            Key findings

            Diabetics on metformin had lower mortality than matched non-diabetics.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Metformin (Longevity Use) — May reduce age-related diseases

            Live PubMed search

            Live results for "Metformin (Longevity Use) May reduce age-related diseases" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Metformin (Longevity Use) and "May reduce age-related diseases". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Metformin (Longevity Use) — randomized controlled trial

            Live PubMed search

            Live results for "Metformin (Longevity Use) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Metformin (Longevity Use) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Metformin (Longevity Use) — meta-analysis

            Live PubMed search

            Live results for "Metformin (Longevity Use) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Metformin (Longevity Use) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Metformin (Longevity Use) — pharmacokinetics

            Live PubMed search

            Live results for "Metformin (Longevity Use) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Metformin (Longevity Use) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Metformin (Longevity Use) — safety adverse events

            Live PubMed search

            Live results for "Metformin (Longevity Use) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Metformin (Longevity Use) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Metformin (Longevity Use) — dose response

            Live PubMed search

            Live results for "Metformin (Longevity Use) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Metformin (Longevity Use) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Metformin (Longevity Use) — clinical evidence

            Live Scholar search

            Cross-database citation index for Metformin (Longevity Use) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.