Overview
Biguanide diabetes drug studied for healthspan.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Inhibits mitochondrial complex I; activates AMPK.
- · Inhibits mitochondrial complex I
- · activates AMPK
Effects on the body
Organ system effects
Metformin (Longevity Use) acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Metformin (Longevity Use) affects hepatic insulin sensitivity, lipid handling, or glucose disposal.
Evidence-based benefits
May reduce age-related diseases
Moderate evidencePotential side effects
- · GI upset
- · B12 deficiency
- · Lactic acidosis (rare)
Drug interactions
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Metformin (Longevity Use) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Metformin (Longevity Use) third party tested NSF
CapsulesPre-measured Metformin (Longevity Use) capsules — easiest for travel and consistent daily dosing without scoops or scales.Metformin (Longevity Use) capsules
PowderBulk unflavored Metformin (Longevity Use) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Metformin (Longevity Use) powder unflavored
Best sellersMost-purchased Metformin (Longevity Use) products on Amazon — a quick way to see what's reviewed widely before you commit.Metformin (Longevity Use) best sellerScientific evidence8Show studiesHide studies
Metformin in non-diabetics (TAME-related)
Bannister CA, et al.
78,000+ adults
Diabetics on metformin had lower mortality than matched non-diabetics.
PubMed: Metformin (Longevity Use) — May reduce age-related diseases
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PubMed: Metformin (Longevity Use) — randomized controlled trial
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Google Scholar: Metformin (Longevity Use) — clinical evidence
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