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evidence · mechanism · dose
Supplements/Nootropic

9-Me-BC

aka 9-Methyl-β-carboline

β-carboline alkaloid that upregulates dopamine neurons in animal models.

Brain & CognitiveHealthy Aging

Overview

β-carboline alkaloid that upregulates dopamine neurons in animal models.

Natural sources
    Common forms

      Mechanism of action

      MAO-A inhibition plus dopaminergic neurogenesis in substantia nigra (rodent data).

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Increases dopamine neuron count in rats

        Limited evidence

        Potential side effects

        Common
        • · Headache
        Rare
          Serious
          • · Limited human safety data

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          10–50 mg (experimental)

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Nootropic
          9-Me-BC
          Amazon
          Wide selection · fast shipping
          Nootropic
          9-Me-BC
          iHerb
          Global delivery · curated brands
          Nootropic
          9-Me-BC
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          AnimalNeurosci Lett · 2010

          9-Me-BC restores dopamine in MPTP-lesioned mice

          Polanski W, et al.

          Mouse Parkinson's model treated with 9-Me-BC.

          Key findings

          Restored striatal dopamine and TH-positive neuron count.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: 9-Me-BC — Increases dopamine neuron count in rats

          Live PubMed search

          Live results for "9-Me-BC Increases dopamine neuron count in rats" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching 9-Me-BC and "Increases dopamine neuron count in rats". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: 9-Me-BC — randomized controlled trial

          Live PubMed search

          Live results for "9-Me-BC randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching 9-Me-BC and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: 9-Me-BC — meta-analysis

          Live PubMed search

          Live results for "9-Me-BC meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching 9-Me-BC and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: 9-Me-BC — pharmacokinetics

          Live PubMed search

          Live results for "9-Me-BC pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching 9-Me-BC and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: 9-Me-BC — safety adverse events

          Live PubMed search

          Live results for "9-Me-BC safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching 9-Me-BC and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: 9-Me-BC — dose response

          Live PubMed search

          Live results for "9-Me-BC dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching 9-Me-BC and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: 9-Me-BC — clinical evidence

          Live Scholar search

          Cross-database citation index for 9-Me-BC as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.