Overview
EVOO ibuprofen-like compound.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
COX inhibitor similar to ibuprofen.
- · COX inhibitor similar to ibuprofen
Effects on the body
Organ system effects
Oleocanthal acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Evidence-based benefits
Anti-inflammatory
Moderate evidencePotential side effects
- · Well tolerated
Drug interactions
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Oleocanthal — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Oleocanthal third party tested NSF
CapsulesPre-measured Oleocanthal capsules — easiest for travel and consistent daily dosing without scoops or scales.Oleocanthal capsules
PowderBulk unflavored Oleocanthal powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Oleocanthal powder unflavored
Best sellersMost-purchased Oleocanthal products on Amazon — a quick way to see what's reviewed widely before you commit.Oleocanthal best sellerScientific evidence8Show studiesHide studies
Oleocanthal pharmacology
Beauchamp GK, et al.
Mechanism review
Comparable to ibuprofen for COX.
PubMed: Oleocanthal — Anti-inflammatory
Live PubMed search
Live results for "Oleocanthal Anti-inflammatory" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Oleocanthal and "Anti-inflammatory". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Oleocanthal — randomized controlled trial
Live PubMed search
Live results for "Oleocanthal randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Oleocanthal and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Oleocanthal — meta-analysis
Live PubMed search
Live results for "Oleocanthal meta-analysis" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Oleocanthal and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Oleocanthal — pharmacokinetics
Live PubMed search
Live results for "Oleocanthal pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Oleocanthal and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Oleocanthal — safety adverse events
Live PubMed search
Live results for "Oleocanthal safety adverse events" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Oleocanthal and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Oleocanthal — dose response
Live PubMed search
Live results for "Oleocanthal dose response" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Oleocanthal and "dose response". Filter by RCT, meta-analysis, or year on the results page.
Google Scholar: Oleocanthal — clinical evidence
Live Scholar search
Cross-database citation index for Oleocanthal as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.