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evidence · mechanism · dose
Supplements/Nootropic

Centrophenoxine

aka Meclofenoxate

Cholinergic precursor that reduces lipofuscin accumulation in neurons.

Brain & CognitiveHealthy Aging

Overview

Cholinergic precursor that reduces lipofuscin accumulation in neurons.

Natural sources
    Common forms

      Mechanism of action

      Hydrolyzed to DMAE and pCPA; raises brain acetylcholine and removes lipofuscin deposits.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Modest cognitive improvement in dementia

        Limited evidence

        Potential side effects

        Common
        • · Insomnia if taken late
        • · GI upset
        Rare
        • · Jaw tension
        Serious

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          250–1000 mg
          With food?
          Morning

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Nootropic
          Centrophenox…
          Amazon
          Wide selection · fast shipping
          Nootropic
          Centrophenox…
          iHerb
          Global delivery · curated brands
          Nootropic
          Centrophenox…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTPharmacopsychiatry · 1992

          Meclofenoxate in dementia

          Fischhof PK, et al.

          DB-RCT in 50 mild-moderate dementia patients.

          Key findings

          Significant improvement vs placebo on Sandoz Clinical Assessment.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Centrophenoxine — Modest cognitive improvement in dementia

          Live PubMed search

          Live results for "Centrophenoxine Modest cognitive improvement in dementia" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Centrophenoxine and "Modest cognitive improvement in dementia". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Centrophenoxine — randomized controlled trial

          Live PubMed search

          Live results for "Centrophenoxine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Centrophenoxine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Centrophenoxine — meta-analysis

          Live PubMed search

          Live results for "Centrophenoxine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Centrophenoxine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Centrophenoxine — pharmacokinetics

          Live PubMed search

          Live results for "Centrophenoxine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Centrophenoxine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Centrophenoxine — safety adverse events

          Live PubMed search

          Live results for "Centrophenoxine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Centrophenoxine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Centrophenoxine — dose response

          Live PubMed search

          Live results for "Centrophenoxine dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Centrophenoxine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Centrophenoxine — clinical evidence

          Live Scholar search

          Cross-database citation index for Centrophenoxine as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.