Overview
Cholinergic precursor that reduces lipofuscin accumulation in neurons.
- Manufactured pharmaceutical-grade compound
- Standardized botanical extract (for plant-derived nootropics)
- Stack formulations combined with cholinergic or adaptogenic ingredients
- Capsule
- Powder for stacking
- Sublingual tablet
- Liposomal liquid
Mechanism of action
Hydrolyzed to DMAE and pCPA; raises brain acetylcholine and removes lipofuscin deposits.
- · Hydrolyzed to DMAE
- · raises brain acetylcholine
- · removes lipofuscin deposits
Effects on the body
Organ system effects
Centrophenoxine acts on central nervous system targets implicated in attention, memory, and neuroprotection.
Evidence-based benefits
Modest cognitive improvement in dementia
Limited evidencePotential side effects
- · Insomnia if taken late
- · GI upset
- · Jaw tension
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
Supplement interactions
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
- Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Centrophenoxine — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Centrophenoxine third party tested NSF
CapsulesPre-measured Centrophenoxine capsules — easiest for travel and consistent daily dosing without scoops or scales.Centrophenoxine capsules
PowderBulk unflavored Centrophenoxine powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Centrophenoxine powder unflavored
Best sellersMost-purchased Centrophenoxine products on Amazon — a quick way to see what's reviewed widely before you commit.Centrophenoxine best sellerScientific evidence8Show studiesHide studies
Meclofenoxate in dementia
Fischhof PK, et al.
DB-RCT in 50 mild-moderate dementia patients.
Significant improvement vs placebo on Sandoz Clinical Assessment.
PubMed: Centrophenoxine — Modest cognitive improvement in dementia
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PubMed: Centrophenoxine — dose response
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Google Scholar: Centrophenoxine — clinical evidence
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