Overview
Bee glue with caffeic acid phenethyl ester.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
CAPE inhibits NF-κB; antiviral.
- · CAPE inhibits NF-κB
- · antiviral
Effects on the body
Organ system effects
Propolis modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Reduces cold sore healing time
Moderate evidencePotential side effects
- · Allergy
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Propolis — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Propolis third party tested NSF
CapsulesPre-measured Propolis capsules — easiest for travel and consistent daily dosing without scoops or scales.Propolis capsules
PowderBulk unflavored Propolis powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Propolis powder unflavored
Best sellersMost-purchased Propolis products on Amazon — a quick way to see what's reviewed widely before you commit.Propolis best sellerScientific evidence8Show studiesHide studies
Propolis for cold sores
Vynograd N, et al.
90 patients
Faster healing than acyclovir.
PubMed: Propolis — Reduces cold sore healing time
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