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evidence · mechanism · dose
Supplements/Herb

American Ginseng

aka Panax quinquefolius

Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.

Immune FunctionBlood Sugar ManagementBrain & Cognitive

Overview

Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.

Natural sources
  • Panax quinquefolius root
Common forms
  • CVT-E002 (Cold-FX)

Mechanism of action

Ginsenosides (different profile than Asian); CVT-E002 modulates innate immunity.

Pathways
  • · Innate immunity
  • · Insulin sensitivity

Effects on the body

Decreases
Postprandial glucose
Decreases
Cold/flu incidence

Organ system effects

Immune System

Reduces URI in elderly.

Evidence-based benefits

Reduces URI incidence and severity (CVT-E002)

Moderate evidence

Lowers postprandial glucose in T2D

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Warfarin
      May reduce INR.
      moderate
      Antidiabetics
      Additive hypoglycemia.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      200–400 mg

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Herb
      American Gin…
      Amazon
      Wide selection · fast shipping
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      iHerb
      Global delivery · curated brands
      Herb
      American Gin…
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (9)

      Systematic reviewExamine.com Supplement Database · 2023

      American Ginseng: pharmacology, clinical evidence, and safety — narrative review

      Examine.com Research Team

      Curated narrative review of human and preclinical evidence for American Ginseng, including mechanism, typical dosing, and safety considerations.

      Key findings

      Best-supported outcome: Reduces URI incidence and severity (CVT-E002) (evidence: moderate). Additional outcomes and limitations summarized in the full profile.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: American Ginseng — Reduces URI incidence and severity

      Live PubMed search

      Live results for "American Ginseng Reduces URI incidence and severity" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching American Ginseng and "Reduces URI incidence and severity". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: American Ginseng — Lowers postprandial glucose in T2D

      Live PubMed search

      Live results for "American Ginseng Lowers postprandial glucose in T2D" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching American Ginseng and "Lowers postprandial glucose in T2D". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: American Ginseng — randomized controlled trial

      Live PubMed search

      Live results for "American Ginseng randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching American Ginseng and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: American Ginseng — meta-analysis

      Live PubMed search

      Live results for "American Ginseng meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching American Ginseng and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: American Ginseng — pharmacokinetics

      Live PubMed search

      Live results for "American Ginseng pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching American Ginseng and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: American Ginseng — safety adverse events

      Live PubMed search

      Live results for "American Ginseng safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching American Ginseng and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: American Ginseng — dose response

      Live PubMed search

      Live results for "American Ginseng dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching American Ginseng and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: American Ginseng — clinical evidence

      Live Scholar search

      Cross-database citation index for American Ginseng as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.