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evidence · mechanism · dose
Supplements/Compound

Idebenone

Synthetic CoQ10 analog with better water solubility; used in LHON.

Brain & CognitiveHealthy AgingEye Health

Overview

Synthetic CoQ10 analog with better water solubility; used in LHON.

Natural sources
    Common forms

      Mechanism of action

      Bypasses Complex I dysfunction by donating electrons directly to Complex III.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Recovers vision in Leber hereditary optic neuropathy

        Strong evidence

        Potential side effects

        Common
        • · GI upset
        • · Discolored urine
        Rare
        • · Liver enzyme elevation
        Serious

          Drug interactions

          No notable interactions reported.

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          270–900 mg (Rx for LHON)
          With food?
          With meals

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Compound
          Idebenone
          Amazon
          Wide selection · fast shipping
          Compound
          Idebenone
          iHerb
          Global delivery · curated brands
          Compound
          Idebenone
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTBrain · 2011

          Idebenone in LHON (RHODOS)

          Klopstock T, et al.

          DB-RCT in 85 LHON patients.

          Key findings

          Idebenone 900 mg/day improved best recovery of visual acuity vs placebo.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Idebenone — Recovers vision in Leber hereditary optic neuropathy

          Live PubMed search

          Live results for "Idebenone Recovers vision in Leber hereditary optic neuropathy" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Idebenone and "Recovers vision in Leber hereditary optic neuropathy". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Idebenone — randomized controlled trial

          Live PubMed search

          Live results for "Idebenone randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Idebenone and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Idebenone — meta-analysis

          Live PubMed search

          Live results for "Idebenone meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Idebenone and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Idebenone — pharmacokinetics

          Live PubMed search

          Live results for "Idebenone pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Idebenone and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Idebenone — safety adverse events

          Live PubMed search

          Live results for "Idebenone safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Idebenone and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Idebenone — dose response

          Live PubMed search

          Live results for "Idebenone dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Idebenone and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Idebenone — clinical evidence

          Live Scholar search

          Cross-database citation index for Idebenone as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.