Overview
Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.
- Trace in red meat, organ meats
- Racemic ALA
- R-ALA (active enantiomer)
Forms & variants of Alpha-Lipoic Acid
Different chemical forms of Alpha-Lipoic Acid behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Cofactor for pyruvate and α-KG dehydrogenase; regenerates other antioxidants; activates AMPK.
- · AMPK activation
- · Antioxidant recycling
Effects on the body
Organ system effects
Reduces diabetic neuropathy pain.
Evidence-based benefits
Reduces diabetic neuropathy symptoms (600 mg/d)
Strong evidencePotential side effects
- · Nausea
- · Skin rash
- · Insulin autoimmune syndrome (rare)
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Thiamine deficiency (e.g. alcohol-use disorder)
- ·Thyroid disorders
- ·Insulin and antidiabetic drugs (hypoglycemia)
- ·Thyroid hormone (reduced absorption)
- ·Chemotherapy
Supplement interactions
None listed.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Scientific evidence (8)
ALA for diabetic peripheral neuropathy (SYDNEY 2)
Ziegler D, et al.
5-week RCT of oral ALA in diabetic neuropathy.
Significant symptom and neuropathic-impairment improvement.
PubMed: Alpha-Lipoic Acid — Reduces diabetic neuropathy symptoms
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PubMed: Alpha-Lipoic Acid — randomized controlled trial
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PubMed: Alpha-Lipoic Acid — meta-analysis
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PubMed: Alpha-Lipoic Acid — pharmacokinetics
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PubMed: Alpha-Lipoic Acid — dose response
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Google Scholar: Alpha-Lipoic Acid — clinical evidence
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Cross-database citation index for Alpha-Lipoic Acid as it relates to "clinical evidence".
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