SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Herb

Cat's Claw

Uncaria tomentosa for joint pain and immunity.

Immune Function

Overview

Uncaria tomentosa for joint pain and immunity.

Natural sources
    Common forms

      Mechanism of action

      Pentacyclic oxindole alkaloids modulate NF-κB.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces RA inflammation

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            250–350 mg standardized

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Cat's Claw
            Amazon
            Wide selection · fast shipping
            Herb
            Cat's Claw
            iHerb
            Global delivery · curated brands
            Herb
            Cat's Claw
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Rheumatol · 2002

            Cat's claw in rheumatoid arthritis

            Mur E, et al.

            40 RA patients

            Key findings

            Reduced tender/swollen joints vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cat's Claw — Reduces RA inflammation

            Live PubMed search

            Live results for "Cat's Claw Reduces RA inflammation" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cat's Claw and "Reduces RA inflammation". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cat's Claw — randomized controlled trial

            Live PubMed search

            Live results for "Cat's Claw randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cat's Claw and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cat's Claw — meta-analysis

            Live PubMed search

            Live results for "Cat's Claw meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cat's Claw and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cat's Claw — pharmacokinetics

            Live PubMed search

            Live results for "Cat's Claw pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cat's Claw and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cat's Claw — safety adverse events

            Live PubMed search

            Live results for "Cat's Claw safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cat's Claw and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cat's Claw — dose response

            Live PubMed search

            Live results for "Cat's Claw dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cat's Claw and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Cat's Claw — clinical evidence

            Live Scholar search

            Cross-database citation index for Cat's Claw as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.