SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Mushroom

Chaga

aka Inonotus obliquus

Birch-tree mushroom rich in melanin, betulin, and antioxidants.

Immune FunctionHealthy Aging

Overview

Birch-tree mushroom rich in melanin, betulin, and antioxidants.

Natural sources
  • Inonotus obliquus
Common forms
  • Dual-extracted powder

Mechanism of action

Polysaccharides and triterpenes; high ORAC antioxidant capacity.

Pathways
  • · Antioxidant
  • · Immune modulation

Effects on the body

Supports
Antioxidant capacity

Organ system effects

Immune System

Polysaccharides stimulate macrophages.

Evidence-based benefits

In vitro & animal data robust; clinical data limited

Limited evidence

Potential side effects

Common
    Rare
      Serious
      • · Oxalate-related kidney concerns at high chronic doses

      Drug interactions

      Anticoagulants
      Antiplatelet effects.
      moderate
      Antidiabetics
      Additive.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with
      • Kidney stones
        High oxalate.

      Dosing & bioavailability

      Typical dose
      1–3 g dual extract

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Mushroom
      Chaga
      Amazon
      Wide selection · fast shipping
      Mushroom
      Chaga
      iHerb
      Global delivery · curated brands
      Mushroom
      Chaga
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      Systematic reviewJ Ethnopharmacol · 2021

      Inonotus obliquus (Chaga) — pharmacology and clinical evidence

      Lu Y, et al.

      Review of Chaga's antioxidant and immunomodulatory effects.

      Key findings

      Promising preclinical data; human trials limited.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Chaga — In vitro & animal data robust; clinical data limited

      Live PubMed search

      Live results for "Chaga In vitro & animal data robust; clinical data limited" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Chaga and "In vitro & animal data robust; clinical data limited". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Chaga — randomized controlled trial

      Live PubMed search

      Live results for "Chaga randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Chaga and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Chaga — meta-analysis

      Live PubMed search

      Live results for "Chaga meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Chaga and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Chaga — pharmacokinetics

      Live PubMed search

      Live results for "Chaga pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Chaga and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Chaga — safety adverse events

      Live PubMed search

      Live results for "Chaga safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Chaga and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Chaga — dose response

      Live PubMed search

      Live results for "Chaga dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Chaga and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Chaga — clinical evidence

      Live Scholar search

      Cross-database citation index for Chaga as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.