Overview
Glycine + NAC combo — restores glutathione in older adults and improves multiple aging markers.
- Dietary protein from animal sources (meat, fish, eggs, dairy) and plant sources (soy, legumes, grains)
- Free-form amino acid powders and capsules
- Targeted pre-workout, recovery, or sleep formulations
- Free-form crystalline powder
- Capsules or tablets
- Pre-mixed recovery or hydration beverages
- Time-release formulations
Mechanism of action
Restores intracellular glutathione, lowering oxidative stress and reversing mitochondrial dysfunction.
- · Restores intracellular glutathione, lowering oxidative stress
- · reversing mitochondrial dysfunction
Effects on the body
Organ system effects
Evidence-based benefits
Improves muscle strength, gait, cognition in older adults (Sekhar 2022)
Moderate evidencePotential side effects
- · GlyNAC (Glycine + NAC) is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified GlyNAC (Glycine + NAC) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.GlyNAC (Glycine + NAC) third party tested NSF
CapsulesPre-measured GlyNAC (Glycine + NAC) capsules — easiest for travel and consistent daily dosing without scoops or scales.GlyNAC (Glycine + NAC) capsules
PowderBulk unflavored GlyNAC (Glycine + NAC) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.GlyNAC (Glycine + NAC) powder unflavored
Best sellersMost-purchased GlyNAC (Glycine + NAC) products on Amazon — a quick way to see what's reviewed widely before you commit.GlyNAC (Glycine + NAC) best sellerScientific evidence8Show studiesHide studies
GlyNAC supplementation in older adults
Kumar P, et al.
16-week RCT of glycine + NAC in older adults.
Restored glutathione, improved mitochondrial function and insulin sensitivity.
PubMed: GlyNAC (Glycine + NAC) — Improves muscle strength, gait, cognition in older adults
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