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evidence · mechanism · dose
Supplements/Amino Acid

GlyNAC (Glycine + NAC)

Glycine + NAC combo — restores glutathione in older adults and improves multiple aging markers.

Longevity PathwaysHealthy Aging (alias)Mitochondrial FunctionAntioxidants

Overview

Glycine + NAC combo — restores glutathione in older adults and improves multiple aging markers.

Natural sources
    Common forms

      Mechanism of action

      Restores intracellular glutathione, lowering oxidative stress and reversing mitochondrial dysfunction.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves muscle strength, gait, cognition in older adults (Sekhar 2022)

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              100 mg/kg glycine + 100 mg/kg NAC daily
              Study range
              Per protocol
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTClin Transl Med · 2021

              GlyNAC supplementation in older adults

              Kumar P, et al.

              16-week RCT of glycine + NAC in older adults.

              Key findings

              Restored glutathione, improved mitochondrial function and insulin sensitivity.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: GlyNAC (Glycine + NAC) — Improves muscle strength, gait, cognition in older adults

              Live PubMed search

              Live results for "GlyNAC (Glycine + NAC) Improves muscle strength, gait, cognition in older adults" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching GlyNAC (Glycine + NAC) and "Improves muscle strength, gait, cognition in older adults". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: GlyNAC (Glycine + NAC) — randomized controlled trial

              Live PubMed search

              Live results for "GlyNAC (Glycine + NAC) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching GlyNAC (Glycine + NAC) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: GlyNAC (Glycine + NAC) — meta-analysis

              Live PubMed search

              Live results for "GlyNAC (Glycine + NAC) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching GlyNAC (Glycine + NAC) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: GlyNAC (Glycine + NAC) — pharmacokinetics

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              Key findings

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              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: GlyNAC (Glycine + NAC) — safety adverse events

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              Key findings

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              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: GlyNAC (Glycine + NAC) — dose response

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              Key findings

              Opens current human and preclinical literature matching GlyNAC (Glycine + NAC) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: GlyNAC (Glycine + NAC) — clinical evidence

              Live Scholar search

              Cross-database citation index for GlyNAC (Glycine + NAC) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.