Overview
PA-free butterbur for allergic rhinitis.
- Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
- Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
- Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
- Standardized extract capsule
- Liquid tincture (alcohol or glycerin)
- Powdered whole herb
- Traditional decoction or tea
Mechanism of action
Inhibits leukotrienes; histamine blocker.
- · Inhibits leukotrienes
- · histamine blocker
Effects on the body
Organ system effects
Butterbur Ze 339 modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Reduces hay fever
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Butterbur Ze 339 — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Butterbur Ze 339 third party tested NSF
CapsulesPre-measured Butterbur Ze 339 capsules — easiest for travel and consistent daily dosing without scoops or scales.Butterbur Ze 339 capsules
PowderBulk unflavored Butterbur Ze 339 powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Butterbur Ze 339 powder unflavored
Best sellersMost-purchased Butterbur Ze 339 products on Amazon — a quick way to see what's reviewed widely before you commit.Butterbur Ze 339 best sellerScientific evidence8Show studiesHide studies
Butterbur for hay fever
Schapowal A
125 patients
Comparable to cetirizine.
PubMed: Butterbur Ze 339 — Reduces hay fever
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