Overview
Active black seed compound.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Anti-inflammatory; NF-κB inhibition.
- · Anti-inflammatory
- · NF-κB inhibition
Effects on the body
Organ system effects
Thymoquinone modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Anti-inflammatory
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Thymoquinone — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Thymoquinone third party tested NSF
CapsulesPre-measured Thymoquinone capsules — easiest for travel and consistent daily dosing without scoops or scales.Thymoquinone capsules
PowderBulk unflavored Thymoquinone powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Thymoquinone powder unflavored
Best sellersMost-purchased Thymoquinone products on Amazon — a quick way to see what's reviewed widely before you commit.Thymoquinone best sellerScientific evidence8Show studiesHide studies
Thymoquinone review
Darakhshan S, et al.
Mechanistic review
Anticancer, anti-inflammatory, and antimicrobial.
PubMed: Thymoquinone — Anti-inflammatory
Live PubMed search
Live results for "Thymoquinone Anti-inflammatory" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Thymoquinone and "Anti-inflammatory". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Thymoquinone — randomized controlled trial
Live PubMed search
Live results for "Thymoquinone randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Thymoquinone and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Thymoquinone — meta-analysis
Live PubMed search
Live results for "Thymoquinone meta-analysis" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Thymoquinone and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Thymoquinone — pharmacokinetics
Live PubMed search
Live results for "Thymoquinone pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Thymoquinone and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Thymoquinone — safety adverse events
Live PubMed search
Live results for "Thymoquinone safety adverse events" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Thymoquinone and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Thymoquinone — dose response
Live PubMed search
Live results for "Thymoquinone dose response" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Thymoquinone and "dose response". Filter by RCT, meta-analysis, or year on the results page.
Google Scholar: Thymoquinone — clinical evidence
Live Scholar search
Cross-database citation index for Thymoquinone as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.