SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Mineral

Selenium (Selenomethionine)

Antioxidant trace element for thyroid.

Hormone BalanceImmune FunctionHealthy Aging

Overview

Antioxidant trace element for thyroid.

Natural sources
    Common forms

      Mechanism of action

      Cofactor for glutathione peroxidase and deiodinases.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces thyroid antibodies

        Moderate evidence

        Potential side effects

        Common
        • · Selenosis at high doses
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            100–200 mcg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Mineral
            Selenium (Se…
            Amazon
            Wide selection · fast shipping
            Mineral
            Selenium (Se…
            iHerb
            Global delivery · curated brands
            Mineral
            Selenium (Se…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Clin Endocrinol Metab · 2002

            Selenium in Hashimoto

            Gartner R, et al.

            70 Hashimoto patients

            Key findings

            Reduced TPO antibodies 40%.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium (Selenomethionine) — Reduces thyroid antibodies

            Live PubMed search

            Live results for "Selenium (Selenomethionine) Reduces thyroid antibodies" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium (Selenomethionine) and "Reduces thyroid antibodies". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium (Selenomethionine) — randomized controlled trial

            Live PubMed search

            Live results for "Selenium (Selenomethionine) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium (Selenomethionine) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium (Selenomethionine) — meta-analysis

            Live PubMed search

            Live results for "Selenium (Selenomethionine) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium (Selenomethionine) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium (Selenomethionine) — pharmacokinetics

            Live PubMed search

            Live results for "Selenium (Selenomethionine) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium (Selenomethionine) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium (Selenomethionine) — safety adverse events

            Live PubMed search

            Live results for "Selenium (Selenomethionine) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium (Selenomethionine) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium (Selenomethionine) — dose response

            Live PubMed search

            Live results for "Selenium (Selenomethionine) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium (Selenomethionine) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Selenium (Selenomethionine) — clinical evidence

            Live Scholar search

            Cross-database citation index for Selenium (Selenomethionine) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.