Overview
Standardized β-glucan from Grifola frondosa for immune support.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
β-glucan activation of macrophages and NK cells via Dectin-1.
- · β-glucan activation of macrophages
- · NK cells via Dectin-1
Effects on the body
Organ system effects
Maitake D-Fraction modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Enhances immune markers in cancer patients
Moderate evidencePotential side effects
- · Maitake D-Fraction is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Maitake D-Fraction — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Maitake D-Fraction third party tested NSF
CapsulesPre-measured Maitake D-Fraction capsules — easiest for travel and consistent daily dosing without scoops or scales.Maitake D-Fraction capsules
PowderBulk unflavored Maitake D-Fraction powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Maitake D-Fraction powder unflavored
Best sellersMost-purchased Maitake D-Fraction products on Amazon — a quick way to see what's reviewed widely before you commit.Maitake D-Fraction best sellerScientific evidence8Show studiesHide studies
Maitake D-Fraction in breast cancer
Deng G, et al.
Dose-ranging trial in 34 postmenopausal breast cancer patients.
Bimodal immune modulation depending on dose.
PubMed: Maitake D-Fraction — Enhances immune markers in cancer patients
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PubMed: Maitake D-Fraction — randomized controlled trial
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