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evidence · mechanism · dose
Supplements/Mushroom

Maitake D-Fraction

Standardized β-glucan from Grifola frondosa for immune support.

Immune FunctionBlood Sugar Management

Overview

Standardized β-glucan from Grifola frondosa for immune support.

Natural sources
    Common forms

      Mechanism of action

      β-glucan activation of macrophages and NK cells via Dectin-1.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Enhances immune markers in cancer patients

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Safety & non-supplemental interactions

              Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

              Avoid if you are
              • ·Pregnant or breastfeeding (insufficient safety data)
              • ·Children under 18 (unless directed by a clinician)
              Avoid with these conditions
              • ·Autoimmune disease (theoretical immune activation)
              Avoid / monitor with these medications
              • ·Immunosuppressants

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              0.5–1 mg/kg D-fraction
              With food?
              Empty stomach

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Mushroom
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              Wide selection · fast shipping
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              iHerb
              Global delivery · curated brands
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              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              CohortJ Soc Integr Oncol · 2009

              Maitake D-Fraction in breast cancer

              Deng G, et al.

              Dose-ranging trial in 34 postmenopausal breast cancer patients.

              Key findings

              Bimodal immune modulation depending on dose.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Maitake D-Fraction — Enhances immune markers in cancer patients

              Live PubMed search

              Live results for "Maitake D-Fraction Enhances immune markers in cancer patients" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Maitake D-Fraction and "Enhances immune markers in cancer patients". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Maitake D-Fraction — randomized controlled trial

              Live PubMed search

              Live results for "Maitake D-Fraction randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Maitake D-Fraction and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Maitake D-Fraction — meta-analysis

              Live PubMed search

              Live results for "Maitake D-Fraction meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Maitake D-Fraction and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Maitake D-Fraction — pharmacokinetics

              Live PubMed search

              Live results for "Maitake D-Fraction pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

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              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Maitake D-Fraction — safety adverse events

              Live PubMed search

              Live results for "Maitake D-Fraction safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

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              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Maitake D-Fraction — dose response

              Live PubMed search

              Live results for "Maitake D-Fraction dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Maitake D-Fraction and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Maitake D-Fraction — clinical evidence

              Live Scholar search

              Cross-database citation index for Maitake D-Fraction as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.