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evidence · mechanism · dose
Supplements/Compound

Alpha-Ketoglutarate (AKG)

TCA-cycle intermediate studied for healthspan and frailty.

Healthy AgingMuscle Growth

Overview

TCA-cycle intermediate studied for healthspan and frailty.

Natural sources
    Common forms

      Mechanism of action

      Substrate for α-KG-dependent dioxygenases (TET, PHD); modulates epigenetic age.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers biological age markers in pilot data

        Limited evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1–2 g (Ca-AKG)
            With food?
            Empty stomach

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Compound
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            CohortAging (Albany) · 2021

            Ca-AKG and biological age

            Demidenko O, et al.

            Open-label trial in 42 adults.

            Key findings

            Average epigenetic age decreased ~8 years over 7 months.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-Ketoglutarate (AKG) — Lowers biological age markers in pilot data

            Live PubMed search

            Live results for "Alpha-Ketoglutarate (AKG) Lowers biological age markers in pilot data" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-Ketoglutarate (AKG) and "Lowers biological age markers in pilot data". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-Ketoglutarate (AKG) — randomized controlled trial

            Live PubMed search

            Live results for "Alpha-Ketoglutarate (AKG) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-Ketoglutarate (AKG) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-Ketoglutarate (AKG) — meta-analysis

            Live PubMed search

            Live results for "Alpha-Ketoglutarate (AKG) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-Ketoglutarate (AKG) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-Ketoglutarate (AKG) — pharmacokinetics

            Live PubMed search

            Live results for "Alpha-Ketoglutarate (AKG) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-Ketoglutarate (AKG) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-Ketoglutarate (AKG) — safety adverse events

            Live PubMed search

            Live results for "Alpha-Ketoglutarate (AKG) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-Ketoglutarate (AKG) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-Ketoglutarate (AKG) — dose response

            Live PubMed search

            Live results for "Alpha-Ketoglutarate (AKG) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-Ketoglutarate (AKG) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Alpha-Ketoglutarate (AKG) — clinical evidence

            Live Scholar search

            Cross-database citation index for Alpha-Ketoglutarate (AKG) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.