Overview
TCA-cycle intermediate studied for healthspan and frailty.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Substrate for α-KG-dependent dioxygenases (TET, PHD); modulates epigenetic age.
- · Substrate for α-KG-dependent dioxygenases (TET, PHD)
- · modulates epigenetic age
Effects on the body
Organ system effects
Alpha-Ketoglutarate (AKG) acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Alpha-Ketoglutarate (AKG) influences muscle protein synthesis, neuromuscular output, or recovery from exercise.
Evidence-based benefits
Lowers biological age markers in pilot data
Limited evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
- Creatine monohydrateFoundational support for strength, power, and lean mass.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Alpha-Ketoglutarate (AKG) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Alpha-Ketoglutarate (AKG) third party tested NSF
CapsulesPre-measured Alpha-Ketoglutarate (AKG) capsules — easiest for travel and consistent daily dosing without scoops or scales.Alpha-Ketoglutarate (AKG) capsules
PowderBulk unflavored Alpha-Ketoglutarate (AKG) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Alpha-Ketoglutarate (AKG) powder unflavored
Best sellersMost-purchased Alpha-Ketoglutarate (AKG) products on Amazon — a quick way to see what's reviewed widely before you commit.Alpha-Ketoglutarate (AKG) best sellerScientific evidence8Show studiesHide studies
Ca-AKG and biological age
Demidenko O, et al.
Open-label trial in 42 adults.
Average epigenetic age decreased ~8 years over 7 months.
PubMed: Alpha-Ketoglutarate (AKG) — Lowers biological age markers in pilot data
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Google Scholar: Alpha-Ketoglutarate (AKG) — clinical evidence
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