Overview
Pineapple proteolytic enzyme.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Cleaves bradykinin; anti-inflammatory.
- · Cleaves bradykinin
- · anti-inflammatory
Effects on the body
Organ system effects
Bromelain modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Reduces post-surgical swelling
Moderate evidencePotential side effects
- · GI upset
- · Bleeding
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Bromelain — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Bromelain third party tested NSF
CapsulesPre-measured Bromelain capsules — easiest for travel and consistent daily dosing without scoops or scales.Bromelain capsules
PowderBulk unflavored Bromelain powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Bromelain powder unflavored
Best sellersMost-purchased Bromelain products on Amazon — a quick way to see what's reviewed widely before you commit.Bromelain best sellerScientific evidence8Show studiesHide studies
Bromelain for OA
Brien S, et al.
9 trials
Reduced OA pain.
PubMed: Bromelain — Reduces post-surgical swelling
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PubMed: Bromelain — randomized controlled trial
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PubMed: Bromelain — meta-analysis
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PubMed: Bromelain — pharmacokinetics
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PubMed: Bromelain — safety adverse events
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PubMed: Bromelain — dose response
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Google Scholar: Bromelain — clinical evidence
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Cross-database citation index for Bromelain as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.