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evidence · mechanism · dose
Supplements/Compound

Bromelain

Pineapple proteolytic enzyme.

Immune Function

Overview

Pineapple proteolytic enzyme.

Natural sources
    Common forms

      Mechanism of action

      Cleaves bradykinin; anti-inflammatory.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces post-surgical swelling

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        • · Bleeding
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–1500 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Bromelain
            Amazon
            Wide selection · fast shipping
            Compound
            Bromelain
            iHerb
            Global delivery · curated brands
            Compound
            Bromelain
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Meta-analysisEvid Based Complement Alternat Med · 2004

            Bromelain for OA

            Brien S, et al.

            9 trials

            Key findings

            Reduced OA pain.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Bromelain — Reduces post-surgical swelling

            Live PubMed search

            Live results for "Bromelain Reduces post-surgical swelling" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Bromelain and "Reduces post-surgical swelling". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Bromelain — randomized controlled trial

            Live PubMed search

            Live results for "Bromelain randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Bromelain and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Bromelain — meta-analysis

            Live PubMed search

            Live results for "Bromelain meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Bromelain and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Bromelain — pharmacokinetics

            Live PubMed search

            Live results for "Bromelain pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Bromelain and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Bromelain — safety adverse events

            Live PubMed search

            Live results for "Bromelain safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Bromelain and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Bromelain — dose response

            Live PubMed search

            Live results for "Bromelain dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Bromelain and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Bromelain — clinical evidence

            Live Scholar search

            Cross-database citation index for Bromelain as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.