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evidence · mechanism · dose
Supplements/Compound

Bovine Colostrum

First milk rich in IgG, lactoferrin, and growth factors for immune and gut support.

Immune FunctionGut HealthAthletic Performance

Overview

First milk rich in IgG, lactoferrin, and growth factors for immune and gut support.

Natural sources
  • Bovine first-milk colostrum
Common forms
  • Standardized IgG colostrum

Mechanism of action

Provides passive immunity (IgG), lactoferrin (antimicrobial), and IGF-1.

Pathways
  • · Passive immunity
  • · Gut barrier

Effects on the body

Supports
Gut barrier
Decreases
URI incidence in athletes

Organ system effects

Digestive / Gut

Reduces NSAID-induced gut permeability.

Evidence-based benefits

Reduces URI incidence in athletes

Moderate evidence

Reduces NSAID-induced gut hyperpermeability

Moderate evidence

Potential side effects

Common
  • · Bloating
Rare
  • · Dairy allergy
Serious

    Drug interactions

    No notable interactions reported.

    Safety & non-supplemental interactions

    Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

    Avoid with these conditions
    • ·Autoimmune disease (theoretical immune activation)
    Avoid / monitor with these medications
    • ·Immunosuppressants

    Supplement interactions

    Pairs well with

    None listed.

    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    10–60 g/d

    Where to buy

    Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Compound
    Bovine Colos…
    Amazon
    Wide selection · fast shipping
    Compound
    Bovine Colos…
    iHerb
    Global delivery · curated brands
    Compound
    Bovine Colos…
    Thorne
    Practitioner-grade · NSF tested

    Scientific evidence (9)

    RCTIndian Pediatr · 2006

    Bovine colostrum and upper respiratory infections

    Patel K, Rana R

    RCT of colostrum in children for URTI prevention.

    Key findings

    Reduced URTI episodes and severity.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Bovine Colostrum — Reduces URI incidence in athletes

    Live PubMed search

    Live results for "Bovine Colostrum Reduces URI incidence in athletes" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Bovine Colostrum and "Reduces URI incidence in athletes". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Bovine Colostrum — Reduces NSAID-induced gut hyperpermeability

    Live PubMed search

    Live results for "Bovine Colostrum Reduces NSAID-induced gut hyperpermeability" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Bovine Colostrum and "Reduces NSAID-induced gut hyperpermeability". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Bovine Colostrum — randomized controlled trial

    Live PubMed search

    Live results for "Bovine Colostrum randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Bovine Colostrum and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Bovine Colostrum — meta-analysis

    Live PubMed search

    Live results for "Bovine Colostrum meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Bovine Colostrum and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Bovine Colostrum — pharmacokinetics

    Live PubMed search

    Live results for "Bovine Colostrum pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Bovine Colostrum and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Bovine Colostrum — safety adverse events

    Live PubMed search

    Live results for "Bovine Colostrum safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Bovine Colostrum and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Bovine Colostrum — dose response

    Live PubMed search

    Live results for "Bovine Colostrum dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Bovine Colostrum and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Bovine Colostrum — clinical evidence

    Live Scholar search

    Cross-database citation index for Bovine Colostrum as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.